@article{doi:10.1002/ana.25197,

title = {Inflammatory intrathecal profiles and cortical damage in multiple sclerosis},

author = {Roberta Magliozzi and Owain W Howell and Richard Nicholas and Carolina Cruciani and Marco Castellaro and Chiara Romualdi and Stefania Rossi and Marco Pitteri and Maria Donata Benedetti and Alberto Gajofatto and Francesca B Pizzini and Stefania Montemezzi and Sarah Rasia and Ruggero Capra and Alessandra Bertoldo and Francesco Facchiano and Salvatore Monaco and Richard Reynolds and Massimiliano Calabrese},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25197},

doi = {10.1002/ana.25197},

year  = {2018},

date = {2018-01-01},

journal = {Annals of Neurology},

volume = {83},

number = {4},

pages = {739-755},

abstract = {Objective Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? Methods To identify possible biomarkers linking meningeal inflammation, GM damage, and disease severity, gene and protein expression were analyzed in meninges and cerebrospinal fluid (CSF) from 27 postmortem secondary progressive MS and 14 control cases. Combined cytokine/chemokine CSF profiling and 3T magnetic resonance imaging (MRI) were performed at diagnosis in 2 independent cohorts of MS patients (35 and 38 subjects) and in 26 non-MS patients. Results Increased expression of proinflammatory cytokines (IFNγ, TNF, IL2, and IL22) and molecules related to sustained B-cell activity and lymphoid-neogenesis (CXCL13, CXCL10, LTα, IL6, and IL10) was detected in the meninges and CSF of postmortem MS cases with high levels of meningeal inflammation and GM demyelination. Similar proinflammatory patterns, including increased levels of CXCL13, TNF, IFNγ, CXCL12, IL6, IL8, and IL10, together with high levels of BAFF, APRIL, LIGHT, TWEAK, sTNFR1, sCD163, MMP2, and pentraxin III, were detected in the CSF of MS patients with higher levels of GM damage at diagnosis. Interpretation A common pattern of intrathecal (meninges and CSF) inflammatory profile strongly correlates with increased cortical pathology, both at the time of diagnosis and at death. These results suggest a role for detailed CSF analysis combined with MRI as a prognostic marker for more aggressive MS. Ann Neurol 2018 Ann Neurol 2018;83:739–755},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{bajrami2018effect,

title = {The effect of fingolimod on focal and diffuse grey matter damage in active MS patients},

author = {Albulena Bajrami and Marco Pitteri and Marco Castellaro and Francesca Pizzini and Chiara Romualdi and Stefania Montemezzi and Salvatore Monaco and Massimiliano Calabrese},

year  = {2018},

date = {2018-01-01},

journal = {Journal of neurology},

volume = {265},

number = {9},

pages = {2154--2161},

publisher = {Springer Berlin Heidelberg},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{scolozzi2018kinetic,

title = {The kinetic of F-18-FDG in lung cancer: compartmental models and voxel analysis},

author = {E Silvestri and V Scolozzi and G Rizzo and L Indovina and M Castellaro and MV Mattoli and S Taralli and P Graziano and G Cardillo and A Bertoldo and and M L Calcagni},

doi = {10.1186/s13550-018-0439-8},

year  = {2018},

date = {2018-01-01},

booktitle = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},

volume = {8},

number = {1},

pages = {88},

organization = {SPRINGER 233 SPRING ST, NEW YORK, NY 10013 USA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{PMID28750494,

title = {Brain PET and functional MRI: why simultaneously using hybrid PET/MR systems?},

author = {Diego Cecchin and Alessandro Palombit and Marco Castellaro and Erica Silvestri and Franco Bui and Henryk Barthel and Osama Sabri and Maurizio Corbetta and Alessandra Bertoldo},

url = {https://doi.org/10.23736/S1824-4785.17.03008-4},

doi = {10.23736/s1824-4785.17.03008-4},

issn = {1824-4785},

year  = {2017},

date = {2017-12-01},

journal = {The quarterly journal of nuclear medicine and molecular imaging},

volume = {61},

number = {4},

pages = {345—359},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{rizzo_tmi_2016,

title = {Bayesian quantification of contrast-enhanced ultrasound images with adaptive inclusion of an irreversible component},

author = {G. Rizzo and M. Tonietto and M. Castellaro and B. Raffeiner and A. Coran and U. Fiocco and R. Stramare and E. Grisan},

doi = {10.1109/TMI.2016.2637698},

issn = {1558-254X},

year  = {2017},

date = {2017-04-07},

journal = {IEEE Transactions on Medical Imaging},

volume = {36},

number = {4},

pages = {1027 - 1036},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid27626222,

title = {On the Role of the Inferior Intraparietal Sulcus in Visual Working Memory for Lateralized Single-feature Objects},

author = { Sabrina Brigadoi and Simone Cutini and Francesca Meconi and Marco Castellaro and Paola Sessa and Mattia Marangon and Alessandra Bertoldo and Pierre Joliceur and Roberto Dell'Acqua},

year  = {2017},

date = {2017-02-01},

journal = {J Cogn Neurosci},

volume = {29},

number = {2},

pages = {337--351},

abstract = {A consolidated practice in cognitive neuroscience is to explore the properties of human visual working memory through the analysis of electromagnetic signals using cued change detection tasks. Under these conditions, EEG/MEG activity increments in the posterior parietal cortex scaling with the number of memoranda are often reported in the hemisphere contralateral to the objects' position in the memory array. This highly replicable finding clashes with several reported failures to observe compatible hemodynamic activity modulations using fMRI or fNIRS in comparable tasks. Here, we reconcile this apparent discrepancy by acquiring fMRI data on healthy participants and employing a cluster analysis to group voxels in the posterior parietal cortex based on their functional response. The analysis identified two distinct subpopulations of voxels in the intraparietal sulcus (IPS) showing a consistent functional response among participants. One subpopulation, located in the superior IPS, showed a bilateral response to the number of objects coded in visual working memory. A different subpopulation, located in the inferior IPS, showed an increased unilateral response when the objects were displayed contralaterally. The results suggest that a cluster of neurons in the inferior IPS is a candidate source of electromagnetic contralateral responses to working memory load in cued change detection tasks.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28213113,

title = {A Variational Bayesian inference method for parametric imaging of PET data},

author = { Marco Castellaro and Gaia Rizzo and Matteo Tonietto and Mattia Veronese and F. E. Turkheimer and M. A. Chappell and Alessandra Bertoldo},

year  = {2017},

date = {2017-02-01},

journal = {Neuroimage},

volume = {150},

pages = {136--149},

keywords = {},

pubstate = {published},

tppubtype = {article}

}