2017
|
Raffeiner, B; Grisan, E; Botsios, C; Stramare, R; Rizzo, G; Bernardi, L; Punzi, L; Ometto, F; Doria, A Grade and location of Power Doppler are predictive of radiographic damage progression in rheumatoid arthritis patients in clinical remission induced by TNFα blockers Journal Article Rheumatology, in press , 2017, ISSN: 1462-0332. Links | BibTeX @article{raffeiner_rheum_2017,
title = {Grade and location of Power Doppler are predictive of radiographic damage progression in rheumatoid arthritis patients in clinical remission induced by TNFα blockers},
author = {B. Raffeiner and E. Grisan and C. Botsios and R. Stramare and G. Rizzo and L. Bernardi and L. Punzi and F. Ometto and A. Doria},
doi = {https://doi.org/10.1093/rheumatology/kex084},
issn = {1462-0332},
year = {2017},
date = {2017-04-20},
journal = {Rheumatology},
volume = {in press},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Rizzo, G; Tonietto, M; Castellaro, M; Raffeiner, B; Coran, A; Fiocco, U; Stramare, R; Grisan, E Bayesian quantification of contrast-enhanced ultrasound images with adaptive inclusion of an irreversible component Journal Article IEEE Transactions on Medical Imaging, 36 (4), pp. 1027 - 1036, 2017, ISSN: 1558-254X. Links | BibTeX @article{rizzo_tmi_2016,
title = {Bayesian quantification of contrast-enhanced ultrasound images with adaptive inclusion of an irreversible component},
author = {G. Rizzo and M. Tonietto and M. Castellaro and B. Raffeiner and A. Coran and U. Fiocco and R. Stramare and E. Grisan},
doi = {10.1109/TMI.2016.2637698},
issn = {1558-254X},
year = {2017},
date = {2017-04-07},
journal = {IEEE Transactions on Medical Imaging},
volume = {36},
number = {4},
pages = {1027 - 1036},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Hooshmand, M; Zordan, D; Testa, Del D; Grisan, E; Rossi, M Boosting the Battery Life of Wearables for Health Monitoring through the Compression of Biosignals Journal Article IEEE Internet of Things Journal , in press , 2017, ISSN: 2327-4662. Links | BibTeX @article{hooshmand_iot_2017,
title = {Boosting the Battery Life of Wearables for Health Monitoring through the Compression of Biosignals},
author = {M. Hooshmand and D. Zordan and D. Del Testa and E. Grisan and M. Rossi},
doi = {10.1109/JIOT.2017.2689164},
issn = {2327-4662},
year = {2017},
date = {2017-03-29},
journal = {IEEE Internet of Things Journal },
volume = {in press},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fiocco, U; Stramare, R; Martini, V; Coran, A; Felicetti, M; Rizzo, G; Tonietto, M; Caso, F; Costa, L; Scanu, A; Oliviero, F; Raffeiner, B; Lunardi, F; Scarpa, R; Rubaltelli, L; Sacerdoti, D; Doria, A; Grisan, E Pixel-based method of contrast-enhanced ultrasound demonstrates the linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F+ IL-23+ CD161+ CD4+ T helper cells in the psoriatic arthritis joints Journal Article Clinical Rheumatology, 36 (2), pp. 391–399, 2017, ISSN: 1434-9949. Links | BibTeX @article{fiocco_clinrheu_2016,
title = {Pixel-based method of contrast-enhanced ultrasound demonstrates the linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F+ IL-23+ CD161+ CD4+ T helper cells in the psoriatic arthritis joints},
author = {U. Fiocco and R. Stramare and V. Martini and A. Coran and M. Felicetti and G. Rizzo and M. Tonietto and F. Caso and L. Costa and A. Scanu and F. Oliviero and B. Raffeiner and F. Lunardi and R. Scarpa and L. Rubaltelli and D. Sacerdoti and A. Doria and E. Grisan},
doi = { 10.1007/s10067-016-3500-x},
issn = {1434-9949},
year = {2017},
date = {2017-02-02},
journal = {Clinical Rheumatology},
volume = {36},
number = {2},
pages = {391–399},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Brigadoi, Sabrina; Cutini, Simone; Meconi, Francesca; Castellaro, Marco; Sessa, Paola; Marangon, Mattia; Bertoldo, Alessandra; Joliceur, Pierre; Dell'Acqua, Roberto On the Role of the Inferior Intraparietal Sulcus in Visual Working Memory for Lateralized Single-feature Objects Journal Article J Cogn Neurosci, 29 (2), pp. 337–351, 2017. Abstract | BibTeX @article{pmid27626222,
title = {On the Role of the Inferior Intraparietal Sulcus in Visual Working Memory for Lateralized Single-feature Objects},
author = { Sabrina Brigadoi and Simone Cutini and Francesca Meconi and Marco Castellaro and Paola Sessa and Mattia Marangon and Alessandra Bertoldo and Pierre Joliceur and Roberto Dell'Acqua},
year = {2017},
date = {2017-02-01},
journal = {J Cogn Neurosci},
volume = {29},
number = {2},
pages = {337--351},
abstract = {A consolidated practice in cognitive neuroscience is to explore the properties of human visual working memory through the analysis of electromagnetic signals using cued change detection tasks. Under these conditions, EEG/MEG activity increments in the posterior parietal cortex scaling with the number of memoranda are often reported in the hemisphere contralateral to the objects' position in the memory array. This highly replicable finding clashes with several reported failures to observe compatible hemodynamic activity modulations using fMRI or fNIRS in comparable tasks. Here, we reconcile this apparent discrepancy by acquiring fMRI data on healthy participants and employing a cluster analysis to group voxels in the posterior parietal cortex based on their functional response. The analysis identified two distinct subpopulations of voxels in the intraparietal sulcus (IPS) showing a consistent functional response among participants. One subpopulation, located in the superior IPS, showed a bilateral response to the number of objects coded in visual working memory. A different subpopulation, located in the inferior IPS, showed an increased unilateral response when the objects were displayed contralaterally. The results suggest that a cluster of neurons in the inferior IPS is a candidate source of electromagnetic contralateral responses to working memory load in cued change detection tasks.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A consolidated practice in cognitive neuroscience is to explore the properties of human visual working memory through the analysis of electromagnetic signals using cued change detection tasks. Under these conditions, EEG/MEG activity increments in the posterior parietal cortex scaling with the number of memoranda are often reported in the hemisphere contralateral to the objects' position in the memory array. This highly replicable finding clashes with several reported failures to observe compatible hemodynamic activity modulations using fMRI or fNIRS in comparable tasks. Here, we reconcile this apparent discrepancy by acquiring fMRI data on healthy participants and employing a cluster analysis to group voxels in the posterior parietal cortex based on their functional response. The analysis identified two distinct subpopulations of voxels in the intraparietal sulcus (IPS) showing a consistent functional response among participants. One subpopulation, located in the superior IPS, showed a bilateral response to the number of objects coded in visual working memory. A different subpopulation, located in the inferior IPS, showed an increased unilateral response when the objects were displayed contralaterally. The results suggest that a cluster of neurons in the inferior IPS is a candidate source of electromagnetic contralateral responses to working memory load in cued change detection tasks. |
Castellaro, Marco; Rizzo, Gaia; Tonietto, Matteo; Veronese, Mattia; Turkheimer, F E; Chappell, M A; Bertoldo, Alessandra A Variational Bayesian inference method for parametric imaging of PET data Journal Article Neuroimage, 150 , pp. 136–149, 2017. BibTeX @article{pmid28213113,
title = {A Variational Bayesian inference method for parametric imaging of PET data},
author = { Marco Castellaro and Gaia Rizzo and Matteo Tonietto and Mattia Veronese and F. E. Turkheimer and M. A. Chappell and Alessandra Bertoldo},
year = {2017},
date = {2017-02-01},
journal = {Neuroimage},
volume = {150},
pages = {136--149},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Visentin, S; Londero, A P; Camerin, M; Grisan, E; Cosmi, E A possible new approach in the prediction of late gestational hypertension: The role of the fetal aortic intima-media thickness Journal Article Medicine, 96 (2), pp. e5515, 2017, ISSN: 1536-5964. Links | BibTeX @article{visentin_aIMT_2017,
title = {A possible new approach in the prediction of late gestational hypertension: The role of the fetal aortic intima-media thickness},
author = {S. Visentin and A.P. Londero and M. Camerin and E. Grisan and E. Cosmi},
doi = {10.1097/MD.0000000000005515},
issn = {1536-5964},
year = {2017},
date = {2017-01-15},
journal = {Medicine},
volume = {96},
number = {2},
pages = {e5515},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Peruzzo, D; Castellaro, M; Pillonetto, G; Bertoldo, A Stable spline deconvolution for dynamic susceptibility contrast MRI Journal Article Magn Reson Med, 2017. BibTeX @article{pmid28070897,
title = {Stable spline deconvolution for dynamic susceptibility contrast MRI},
author = { D. Peruzzo and M. Castellaro and G. Pillonetto and A. Bertoldo},
year = {2017},
date = {2017-01-01},
journal = {Magn Reson Med},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Calabrese, Massimiliano; Castellaro, Marco Cortical Gray Matter MR Imaging in Multiple Sclerosis Journal Article Neuroimaging Clinics of North America, 2017. BibTeX @article{calabrese2017cortical,
title = {Cortical Gray Matter MR Imaging in Multiple Sclerosis},
author = { Massimiliano Calabrese and Marco Castellaro},
year = {2017},
date = {2017-01-01},
journal = {Neuroimaging Clinics of North America},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2016
|
Calabrese, Massimiliano; Castellaro, Marco; Bertoldo, Alessandra; Luca, Alberto De; Pizzini, Francesca Benedetta; Ricciardi, Giuseppe Kenneth; Pitteri, Marco; Zimatore, Sergio; Magliozzi, Roberta; Benedetti, M D; Manganotti, Paolo; Montemezzi, Stefania; Reynolds, Richard; Gajofatto, Alberto; Monaco, Salvatore Epilepsy in multiple sclerosis: The role of temporal lobe damage Journal Article Mult. Scler., 2016. Abstract | BibTeX @article{pmid27260699,
title = {Epilepsy in multiple sclerosis: The role of temporal lobe damage},
author = { Massimiliano Calabrese and Marco Castellaro and Alessandra Bertoldo and Alberto De Luca and Francesca Benedetta Pizzini and Giuseppe Kenneth Ricciardi and Marco Pitteri and Sergio Zimatore and Roberta Magliozzi and M. D. Benedetti and Paolo Manganotti and Stefania Montemezzi and Richard Reynolds and Alberto Gajofatto and Salvatore Monaco},
year = {2016},
date = {2016-06-01},
journal = {Mult. Scler.},
abstract = {Although temporal lobe pathology may explain some of the symptoms of multiple sclerosis (MS), its role in the pathogenesis of seizures has not been clarified yet. To investigate the role of temporal lobe damage in MS patients suffering from epilepsy, by the application of advanced multimodal 3T magnetic resonance imaging (MRI) analysis. A total of 23 relapsing remitting MS patients who had epileptic seizures (RRMS/E) and 23 disease duration matched RRMS patients without any history of seizures were enrolled. Each patient underwent advanced 3T MRI protocol specifically conceived to evaluate grey matter (GM) damage. This includes grey matter lesions (GMLs) identification, evaluation of regional cortical thickness and indices derived from the Neurite Orientation Dispersion and Density Imaging model. Regional analysis revealed that in RRMS/E, the regions most affected by GMLs were the hippocampus (14.2%), the lateral temporal lobe (13.5%), the cingulate (10.0%) and the insula (8.4%). Cortical thinning and alteration of diffusion metrics were observed in several regions of temporal lobe, in insular cortex and in cingulate gyrus of RRMS/E compared to RRMS (p< 0.05 for all comparisons). Compared to RRMS, RRMS/E showed more severe damage of temporal lobe, which exceeds what would be expected on the basis of the global GM damage observed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Although temporal lobe pathology may explain some of the symptoms of multiple sclerosis (MS), its role in the pathogenesis of seizures has not been clarified yet. To investigate the role of temporal lobe damage in MS patients suffering from epilepsy, by the application of advanced multimodal 3T magnetic resonance imaging (MRI) analysis. A total of 23 relapsing remitting MS patients who had epileptic seizures (RRMS/E) and 23 disease duration matched RRMS patients without any history of seizures were enrolled. Each patient underwent advanced 3T MRI protocol specifically conceived to evaluate grey matter (GM) damage. This includes grey matter lesions (GMLs) identification, evaluation of regional cortical thickness and indices derived from the Neurite Orientation Dispersion and Density Imaging model. Regional analysis revealed that in RRMS/E, the regions most affected by GMLs were the hippocampus (14.2%), the lateral temporal lobe (13.5%), the cingulate (10.0%) and the insula (8.4%). Cortical thinning and alteration of diffusion metrics were observed in several regions of temporal lobe, in insular cortex and in cingulate gyrus of RRMS/E compared to RRMS (p< 0.05 for all comparisons). Compared to RRMS, RRMS/E showed more severe damage of temporal lobe, which exceeds what would be expected on the basis of the global GM damage observed. |
Veronese, Mattia; Rizzo, Gaia; Bertoldo, Alessandra; Turkheimer, Federico E Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications Journal Article Computational and Mathematical Methods in Medicine, 2016 , pp. 1–15, 2016, ISSN: 1748-670X. Abstract | Links | BibTeX @article{Veronese2016,
title = {Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications},
author = { Mattia Veronese and Gaia Rizzo and Alessandra Bertoldo and Federico E Turkheimer},
url = {https://www.hindawi.com/journals/cmmm/2016/7187541/},
doi = {10.1155/2016/7187541},
issn = {1748-670X},
year = {2016},
date = {2016-01-01},
journal = {Computational and Mathematical Methods in Medicine},
volume = {2016},
pages = {1--15},
abstract = {In Positron Emission Tomography (PET), spectral analysis (SA) allows the quantification of dynamic data by relating the radioactivity measured by the scanner in time to the underlying physiological processes of the system under investigation. Among the different approaches for the quantification of PET data, SA is based on the linear solution of the Laplace transform inversion whereas the measured arterial and tissue time-activity curves of a radiotracer are used to calculate the input response function of the tissue. In the recent years SA has been used with a large number of PET tracers in brain and nonbrain applications, demonstrating that it is a very flexible and robust method for PET data analysis. Differently from the most common PET quantification approaches that adopt standard nonlinear estimation of compartmental models or some linear simplifications, SA can be applied without defining any specific model configuration and has demonstrated very good sensitivity to the underlying kinetics. This characteristic makes it useful as an investigative tool especially for the analysis of novel PET tracers. The purpose of this work is to offer an overview of SA, to discuss advantages and limitations of the methodology, and to inform about its applications in the PET field.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In Positron Emission Tomography (PET), spectral analysis (SA) allows the quantification of dynamic data by relating the radioactivity measured by the scanner in time to the underlying physiological processes of the system under investigation. Among the different approaches for the quantification of PET data, SA is based on the linear solution of the Laplace transform inversion whereas the measured arterial and tissue time-activity curves of a radiotracer are used to calculate the input response function of the tissue. In the recent years SA has been used with a large number of PET tracers in brain and nonbrain applications, demonstrating that it is a very flexible and robust method for PET data analysis. Differently from the most common PET quantification approaches that adopt standard nonlinear estimation of compartmental models or some linear simplifications, SA can be applied without defining any specific model configuration and has demonstrated very good sensitivity to the underlying kinetics. This characteristic makes it useful as an investigative tool especially for the analysis of novel PET tracers. The purpose of this work is to offer an overview of SA, to discuss advantages and limitations of the methodology, and to inform about its applications in the PET field. |
Veronese, Mattia; Rizzo, Gaia; Bertoldo, Alessandra; Turkheimer, Federico E Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications Journal Article Computational and Mathematical Methods in Medicine, 2016 , pp. 1–15, 2016, ISSN: 1748-670X. Abstract | Links | BibTeX @article{Veronese2016b,
title = {Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications},
author = { Mattia Veronese and Gaia Rizzo and Alessandra Bertoldo and Federico E Turkheimer},
url = {https://www.hindawi.com/journals/cmmm/2016/7187541/},
doi = {10.1155/2016/7187541},
issn = {1748-670X},
year = {2016},
date = {2016-01-01},
journal = {Computational and Mathematical Methods in Medicine},
volume = {2016},
pages = {1--15},
abstract = {In Positron Emission Tomography (PET), spectral analysis (SA) allows the quantification of dynamic data by relating the radioactivity measured by the scanner in time to the underlying physiological processes of the system under investigation. Among the different approaches for the quantification of PET data, SA is based on the linear solution of the Laplace transform inversion whereas the measured arterial and tissue time-activity curves of a radiotracer are used to calculate the input response function of the tissue. In the recent years SA has been used with a large number of PET tracers in brain and nonbrain applications, demonstrating that it is a very flexible and robust method for PET data analysis. Differently from the most common PET quantification approaches that adopt standard nonlinear estimation of compartmental models or some linear simplifications, SA can be applied without defining any specific model configuration and has demonstrated very good sensitivity to the underlying kinetics. This characteristic makes it useful as an investigative tool especially for the analysis of novel PET tracers. The purpose of this work is to offer an overview of SA, to discuss advantages and limitations of the methodology, and to inform about its applications in the PET field.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In Positron Emission Tomography (PET), spectral analysis (SA) allows the quantification of dynamic data by relating the radioactivity measured by the scanner in time to the underlying physiological processes of the system under investigation. Among the different approaches for the quantification of PET data, SA is based on the linear solution of the Laplace transform inversion whereas the measured arterial and tissue time-activity curves of a radiotracer are used to calculate the input response function of the tissue. In the recent years SA has been used with a large number of PET tracers in brain and nonbrain applications, demonstrating that it is a very flexible and robust method for PET data analysis. Differently from the most common PET quantification approaches that adopt standard nonlinear estimation of compartmental models or some linear simplifications, SA can be applied without defining any specific model configuration and has demonstrated very good sensitivity to the underlying kinetics. This characteristic makes it useful as an investigative tool especially for the analysis of novel PET tracers. The purpose of this work is to offer an overview of SA, to discuss advantages and limitations of the methodology, and to inform about its applications in the PET field. |
Rizzo Gaia Veronese Mattia, Expert Paul Turkheimer Federico Alessandra Bertoldo E MENGA: A New Comprehensive Tool for the Integration of Neuroimaging Data and the Allen Human Brain Transcriptome Atlas Journal Article PLoS ONE, 11 (2), pp. e0148744, 2016. Abstract | Links | BibTeX @article{10.1371/journal.pone.0148744,
title = {MENGA: A New Comprehensive Tool for the Integration of Neuroimaging Data and the Allen Human Brain Transcriptome Atlas},
author = {Rizzo Gaia, Veronese Mattia, Expert Paul, Turkheimer Federico E., Alessandra Bertoldo },
url = {http://dx.doi.org/10.1371%2Fjournal.pone.0148744},
doi = {10.1371/journal.pone.0148744},
year = {2016},
date = {2016-01-01},
journal = {PLoS ONE},
volume = {11},
number = {2},
pages = {e0148744},
publisher = {Public Library of Science},
abstract = { Introduction Brain-wide mRNA mappings offer a great potential for neuroscience research as they can provide information about system proteomics. In a previous work we have correlated mRNA maps with the binding patterns of radioligands targeting specific molecular systems and imaged with positron emission tomography (PET) in unrelated control groups. This approach is potentially applicable to any imaging modality as long as an efficient procedure of imaging-genomic matching is provided. In the original work we considered mRNA brain maps of the whole human genome derived from the Allen human brain database (ABA) and we performed the analysis with a specific region-based segmentation with a resolution that was limited by the PET data parcellation. There we identified the need for a platform for imaging-genomic integration that should be usable with any imaging modalities and fully exploit the high resolution mapping of ABA dataset. Aim In this work we present MENGA (Multimodal Environment for Neuroimaging and Genomic Analysis), a software platform that allows the investigation of the correlation patterns between neuroimaging data of any sort (both functional and structural) with mRNA gene expression profiles derived from the ABA database at high resolution. Results We applied MENGA to six different imaging datasets from three modalities (PET, single photon emission tomography and magnetic resonance imaging) targeting the dopamine and serotonin receptor systems and the myelin molecular structure. We further investigated imaging-genomic correlations in the case of mismatch between selected proteins and imaging targets. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
<sec id="sec001"> <title>Introduction</title> <p>Brain-wide mRNA mappings offer a great potential for neuroscience research as they can provide information about system proteomics. In a previous work we have correlated mRNA maps with the binding patterns of radioligands targeting specific molecular systems and imaged with positron emission tomography (PET) in unrelated control groups. This approach is potentially applicable to any imaging modality as long as an efficient procedure of imaging-genomic matching is provided. In the original work we considered mRNA brain maps of the whole human genome derived from the Allen human brain database (ABA) and we performed the analysis with a specific region-based segmentation with a resolution that was limited by the PET data parcellation. There we identified the need for a platform for imaging-genomic integration that should be usable with any imaging modalities and fully exploit the high resolution mapping of ABA dataset.</p> </sec> <sec id="sec002"> <title>Aim</title> <p>In this work we present MENGA (Multimodal Environment for Neuroimaging and Genomic Analysis), a software platform that allows the investigation of the correlation patterns between neuroimaging data of any sort (both functional and structural) with mRNA gene expression profiles derived from the ABA database at high resolution.</p> </sec> <sec id="sec003"> <title>Results</title> <p>We applied MENGA to six different imaging datasets from three modalities (PET, single photon emission tomography and magnetic resonance imaging) targeting the dopamine and serotonin receptor systems and the myelin molecular structure. We further investigated imaging-genomic correlations in the case of mismatch between selected proteins and imaging targets.</p> </sec> |
Veronese, Mattia; Zanotti-Fregonara, Paolo; Rizzo, Gaia; Bertoldo, Alessandra; Innis, Robert B; Turkheimer, Federico E Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot Journal Article NeuroImage, 130 , pp. 1 - 12, 2016, ISSN: 1053-8119. Abstract | Links | BibTeX @article{Veronese20161,
title = {Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot},
author = {Mattia Veronese and Paolo Zanotti-Fregonara and Gaia Rizzo and Alessandra Bertoldo and Robert B. Innis and Federico E. Turkheimer},
url = {http://www.sciencedirect.com/science/article/pii/S1053811916000732},
doi = {http://dx.doi.org/10.1016/j.neuroimage.2016.01.058},
issn = {1053-8119},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage},
volume = {130},
pages = {1 - 12},
abstract = {Abstract PET studies allow in vivo imaging of the density of brain receptor species. The PET signal, however, is the sum of the fraction of radioligand that is specifically bound to the target receptor and the non-displaceable fraction (i.e. the non-specifically bound radioligand plus the free ligand in tissue). Therefore, measuring the non-displaceable fraction, which is generally assumed to be constant across the brain, is a necessary step to obtain regional estimates of the specific fractions. The nondisplaceable binding can be directly measured if a reference region, i.e. a region devoid of any specific binding, is available. Many receptors are however widely expressed across the brain, and a true reference region is rarely available. In these cases, the nonspecific binding can be obtained after competitive pharmacological blockade, which is often contraindicated in humans. In this work we introduce the genomic plot for estimating the nondisplaceable fraction using baseline scans only. The genomic plot is a transformation of the Lassen graphical method in which the brain maps of mRNA transcripts of the target receptor obtained from the Allen brain atlas are used as a surrogate measure of the specific binding. Thus, the genomic plot allows the calculation of the specific and nondisplaceable components of radioligand uptake without the need of pharmacological blockade. We first assessed the statistical properties of the method with computer simulations. Then we sought ground-truth validation using human PET datasets of seven different neuroreceptor radioligands, where nonspecific fractions were either obtained separately using drug displacement or available from a true reference region. The population nondisplaceable fractions estimated by the genomic plot were very close to those measured by actual human blocking studies (mean relative difference between 2% and 7%). However, these estimates were valid only when mRNA expressions were predictive of protein levels (i.e. there were no significant post-transcriptional changes). This condition can be readily established a priori by assessing the correlation between PET and mRNA expression.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract PET studies allow in vivo imaging of the density of brain receptor species. The PET signal, however, is the sum of the fraction of radioligand that is specifically bound to the target receptor and the non-displaceable fraction (i.e. the non-specifically bound radioligand plus the free ligand in tissue). Therefore, measuring the non-displaceable fraction, which is generally assumed to be constant across the brain, is a necessary step to obtain regional estimates of the specific fractions. The nondisplaceable binding can be directly measured if a reference region, i.e. a region devoid of any specific binding, is available. Many receptors are however widely expressed across the brain, and a true reference region is rarely available. In these cases, the nonspecific binding can be obtained after competitive pharmacological blockade, which is often contraindicated in humans. In this work we introduce the genomic plot for estimating the nondisplaceable fraction using baseline scans only. The genomic plot is a transformation of the Lassen graphical method in which the brain maps of mRNA transcripts of the target receptor obtained from the Allen brain atlas are used as a surrogate measure of the specific binding. Thus, the genomic plot allows the calculation of the specific and nondisplaceable components of radioligand uptake without the need of pharmacological blockade. We first assessed the statistical properties of the method with computer simulations. Then we sought ground-truth validation using human PET datasets of seven different neuroreceptor radioligands, where nonspecific fractions were either obtained separately using drug displacement or available from a true reference region. The population nondisplaceable fractions estimated by the genomic plot were very close to those measured by actual human blocking studies (mean relative difference between 2% and 7%). However, these estimates were valid only when mRNA expressions were predictive of protein levels (i.e. there were no significant post-transcriptional changes). This condition can be readily established a priori by assessing the correlation between PET and mRNA expression. |
Bloomfield, Peter S; Selvaraj, Sudhakar; Veronese, Mattia; Rizzo, Gaia; Bertoldo, Alessandra; Owen, David R; Bloomfield, Michael A P; Bonoldi, Ilaria; Kalk, Nicola; Turkheimer, Federico; McGuire, Philip; de Paola, Vincenzo; Howes, Oliver D Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study Journal Article American Journal of Psychiatry, 173 (1), pp. 44-52, 2016, (PMID: 26472628). Links | BibTeX @article{doi:10.1176/appi.ajp.2015.14101358,
title = {Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study},
author = {Peter S. Bloomfield and Sudhakar Selvaraj and Mattia Veronese and Gaia Rizzo and Alessandra Bertoldo and David R. Owen and Michael A.P. Bloomfield and Ilaria Bonoldi and Nicola Kalk and Federico Turkheimer and Philip McGuire and Vincenzo de Paola and Oliver D. Howes},
url = {http://dx.doi.org/10.1176/appi.ajp.2015.14101358},
doi = {10.1176/appi.ajp.2015.14101358},
year = {2016},
date = {2016-01-01},
journal = {American Journal of Psychiatry},
volume = {173},
number = {1},
pages = {44-52},
note = {PMID: 26472628},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Antonino Vallesi Eleonora Mastrorilli, Francesco Causin Domenico D’Avella Alessandra Bertoldo White matter and task-switching in young adults: A Diffusion Tensor Imaging study Journal Article Neuroscience, 329 , pp. 349-362, 2016, ISSN: 03064522. Abstract | Links | BibTeX @article{Vallesi2016349,
title = {White matter and task-switching in young adults: A Diffusion Tensor Imaging study},
author = {Antonino Vallesi, Eleonora Mastrorilli, Francesco Causin, Domenico D’Avella, Alessandra Bertoldo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84973575890&partnerID=40&md5=aff9137bb27092c0b7187dc94d9c7748},
doi = {10.1016/j.neuroscience.2016.05.026},
issn = {03064522},
year = {2016},
date = {2016-01-01},
journal = {Neuroscience},
volume = {329},
pages = {349-362},
publisher = {Elsevier Ltd},
abstract = {The capacity to flexibly switch between different task rules has been previously associated with distributed fronto-parietal networks, predominantly in the left hemisphere for phasic switching sub-processes, and in the right hemisphere for more tonic aspects of task-switching, such as rule maintenance and management. It is thus likely that the white matter (WM) connectivity between these regions is critical in sustaining the flexibility required by task-switching. This study examined the relationship between WM microstructure in young adults and task-switching performance in different paradigms: classical shape-color, spatial and grammatical tasks. The main results showed an association between WM integrity in anterior portions of the corpus callosum (genu and body) and a sustained measure of task-switching performance. In particular, a higher fractional anisotropy and a lower radial diffusivity in these WM regions were associated with smaller mixing costs both in the spatial task-switching paradigm and in the shape-color one, as confirmed by a conjunction analysis. No association was found with behavioral measures obtained in the grammatical task-switching paradigm. The switch costs, a measure of phasic switching processes, were not correlated with WM microstructure in any task. This study shows that a more efficient inter-hemispheric connectivity within the frontal lobes favors sustained task-switching processes, especially with task contexts embedding non-verbal components. © 2016 The Author(s).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The capacity to flexibly switch between different task rules has been previously associated with distributed fronto-parietal networks, predominantly in the left hemisphere for phasic switching sub-processes, and in the right hemisphere for more tonic aspects of task-switching, such as rule maintenance and management. It is thus likely that the white matter (WM) connectivity between these regions is critical in sustaining the flexibility required by task-switching. This study examined the relationship between WM microstructure in young adults and task-switching performance in different paradigms: classical shape-color, spatial and grammatical tasks. The main results showed an association between WM integrity in anterior portions of the corpus callosum (genu and body) and a sustained measure of task-switching performance. In particular, a higher fractional anisotropy and a lower radial diffusivity in these WM regions were associated with smaller mixing costs both in the spatial task-switching paradigm and in the shape-color one, as confirmed by a conjunction analysis. No association was found with behavioral measures obtained in the grammatical task-switching paradigm. The switch costs, a measure of phasic switching processes, were not correlated with WM microstructure in any task. This study shows that a more efficient inter-hemispheric connectivity within the frontal lobes favors sustained task-switching processes, especially with task contexts embedding non-verbal components. © 2016 The Author(s). |
Elisabetta Grecchi Mattia Veronese, Rosa Maria Moresco Giacomo Bellani Antonio Pesenti Cristina Messa Alessandra Bertoldo Quantification of Dynamic [18F]FDG Pet Studies in Acute Lung Injury Journal Article Molecular Imaging and Biology, 18 (1), pp. 143-152, 2016, ISSN: 15361632. Abstract | Links | BibTeX @article{Grecchi2016143,
title = {Quantification of Dynamic [18F]FDG Pet Studies in Acute Lung Injury},
author = {Elisabetta Grecchi, Mattia Veronese, Rosa Maria Moresco, Giacomo Bellani, Antonio Pesenti, Cristina Messa, Alessandra Bertoldo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955741677&partnerID=40&md5=955b18bafd35e602666a71c935d2d79b},
doi = {10.1007/s11307-015-0871-3},
issn = {15361632},
year = {2016},
date = {2016-01-01},
journal = {Molecular Imaging and Biology},
volume = {18},
number = {1},
pages = {143-152},
publisher = {Springer New York LLC},
abstract = {Purpose: This work aims to investigate lung glucose metabolism using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) positron emission tomography (PET) imaging in acute lung injury (ALI) patients. Procedures: Eleven ALI patients and five healthy controls underwent a dynamic [18F]FDG PET/X-ray computed tomography (CT) scan. The standardized uptake values (SUV) and three different methods for the quantification of glucose metabolism (i.e., ratio, Patlak, and spectral analysis iterative filter, SAIF) were applied both at the region and the voxel levels. Results: SUV reported a lower correlation than the ratio with the net tracer uptake. Patlak and SAIF analyses did not show any significant spatial or quantitative (R2 > 0.80) difference. The additional information provided by SAIF showed that in lung inflammation, elevated tracer uptake is coupled with abnormal tracer exchanges within and between lung tissue compartments. Conclusions: Full kinetic modeling provides a multi-parametric description of glucose metabolism in the lungs. This allows characterizing the spatial distribution of lung inflammation as well as returning the functional state of the tissues. © 2015, World Molecular Imaging Society.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Purpose: This work aims to investigate lung glucose metabolism using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) positron emission tomography (PET) imaging in acute lung injury (ALI) patients. Procedures: Eleven ALI patients and five healthy controls underwent a dynamic [18F]FDG PET/X-ray computed tomography (CT) scan. The standardized uptake values (SUV) and three different methods for the quantification of glucose metabolism (i.e., ratio, Patlak, and spectral analysis iterative filter, SAIF) were applied both at the region and the voxel levels. Results: SUV reported a lower correlation than the ratio with the net tracer uptake. Patlak and SAIF analyses did not show any significant spatial or quantitative (R2 > 0.80) difference. The additional information provided by SAIF showed that in lung inflammation, elevated tracer uptake is coupled with abnormal tracer exchanges within and between lung tissue compartments. Conclusions: Full kinetic modeling provides a multi-parametric description of glucose metabolism in the lungs. This allows characterizing the spatial distribution of lung inflammation as well as returning the functional state of the tissues. © 2015, World Molecular Imaging Society. |
Matteo Tonietto Gaia Rizzo, Mattia Veronese Masahiro Fujita Sami Zoghbi Paolo Zanotti-Fregonara Alessandra Bertoldo S Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches Journal Article Journal of Cerebral Blood Flow and Metabolism, 36 (2), pp. 326-339, 2016, ISSN: 0271678X. Abstract | Links | BibTeX @article{Tonietto2016326,
title = {Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches},
author = {Matteo Tonietto, Gaia Rizzo, Mattia Veronese, Masahiro Fujita, Sami S Zoghbi, Paolo Zanotti-Fregonara, Alessandra Bertoldo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961388641&partnerID=40&md5=caddf72668b5cba353c0ec8429066a39},
doi = {10.1177/0271678X15610585},
issn = {0271678X},
year = {2016},
date = {2016-01-01},
journal = {Journal of Cerebral Blood Flow and Metabolism},
volume = {36},
number = {2},
pages = {326-339},
publisher = {Nature Publishing Group},
abstract = {Full kinetic modeling of dynamic PET images requires the measurement of radioligand concentrations in the arterial plasma. The unchanged parent radioligand must, however, be separated from its radiometabolites by chromatographic methods. Thus, only few samples can usually be analyzed and the resulting measurements are often noisy. Therefore, the measurements must be fitted with a mathematical model. This work presents a comprehensive analysis of the different models proposed in the literature to describe the plasma parent fraction (PPf) and of the alternative approaches for radiometabolite correction. Finally, we used a dataset of [ 11 C]PBR28 brain PET data as a case study to guide the reader through the PPf model selection process. © The Author(s) 2015.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Full kinetic modeling of dynamic PET images requires the measurement of radioligand concentrations in the arterial plasma. The unchanged parent radioligand must, however, be separated from its radiometabolites by chromatographic methods. Thus, only few samples can usually be analyzed and the resulting measurements are often noisy. Therefore, the measurements must be fitted with a mathematical model. This work presents a comprehensive analysis of the different models proposed in the literature to describe the plasma parent fraction (PPf) and of the alternative approaches for radiometabolite correction. Finally, we used a dataset of [ 11 C]PBR28 brain PET data as a case study to guide the reader through the PPf model selection process. © The Author(s) 2015. |
2015
|
Rizzo, Gaia; Raffeiner, Bernd; Coran, Alessandro; Ciprian, Luca; Fiocco, Ugo; Botsios, Costantino; Stramare, Roberto; Grisan, Enrico Pixel-based approach to assess CEUS kinetics parameters for differential diagnosis of rheumatoid arthritis. Journal Article Journal of Medical Imaging, 2 (3), pp. 034503-1 034503-13, 2015. Links | BibTeX @article{rizzo2015,
title = {Pixel-based approach to assess CEUS kinetics parameters for differential diagnosis of rheumatoid arthritis.},
author = {Gaia Rizzo and Bernd Raffeiner and Alessandro Coran and Luca Ciprian and Ugo Fiocco and Costantino Botsios and Roberto Stramare and Enrico Grisan},
doi = {dx.doi.org/10.1117/1.JMI.2.3.034503},
year = {2015},
date = {2015-09-11},
journal = {Journal of Medical Imaging},
volume = {2},
number = {3},
pages = {034503-1 034503-13},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Turkheimer, Federico E; Rizzo, Gaia; Bloomfield, Peter S; Howes, Owen D; Zanotti-Fregonara, Paolo; Bertoldo, Alessandra; Veronese, Mattia The methodology of TSPO imaging with Positron Emission Tomography Journal Article Biochemical Soc Transactions, 43 (4), pp. 586-592, 2015. Links | BibTeX @article{Turkheimer2015,
title = {The methodology of TSPO imaging with Positron Emission Tomography},
author = { Federico E. Turkheimer and Gaia Rizzo and Peter S. Bloomfield and Owen D. Howes and Paolo Zanotti-Fregonara and Alessandra Bertoldo and Mattia Veronese},
doi = { http://dx.doi.org/10.1042/BST20150058},
year = {2015},
date = {2015-08-03},
journal = {Biochemical Soc Transactions},
volume = {43},
number = {4},
pages = {586-592},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Tonietto, Matteo; Veronese, Mattia; Rizzo, Gaia; Zanotti-Fregonara, Paolo; Lohith, Talakad G; Fujita, Masahiro; Zoghbi, Sami S; Bertoldo, Alessandra Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies Journal Article J Cereb Blood Flow Metab, 35 (9), pp. 1462-1469, 2015, ISSN: 0271-678x. Links | BibTeX @article{Tonietto2015a,
title = {Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies},
author = { Matteo Tonietto and Mattia Veronese and Gaia Rizzo and Paolo Zanotti-Fregonara and Talakad G. Lohith and Masahiro Fujita and Sami S. Zoghbi and Alessandra Bertoldo},
url = {http://www.nature.com/jcbfm/journal/v35/n9/full/jcbfm201561a.html},
doi = {10.1038/jcbfm.2015.61},
issn = {0271-678x},
year = {2015},
date = {2015-04-15},
journal = {J Cereb Blood Flow Metab},
volume = {35},
number = {9},
pages = {1462-1469},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Squarcina, Letizia; Luca, Alberto De; Bellani, Marcella; Brambilla, Paolo; Turkheimer, Federico E; Bertoldo, Alessandra Fractal analysis of MRI data for the characterization of patients with schizophrenia and bipolar disorder Journal Article Physics in Medicine and Biology, 60 (4), pp. 1697-1716, 2015. Links | BibTeX @article{Squarcina20151697,
title = {Fractal analysis of MRI data for the characterization of patients with schizophrenia and bipolar disorder},
author = { Letizia Squarcina and Alberto De Luca and Marcella Bellani and Paolo Brambilla and Federico E. Turkheimer and Alessandra Bertoldo},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922309065&partnerID=40&md5=09d4981a2e5856322de548ebcfdc2216},
doi = {10.1088/0031-9155/60/4/1697},
year = {2015},
date = {2015-01-01},
journal = {Physics in Medicine and Biology},
volume = {60},
number = {4},
pages = {1697-1716},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fiocco, Ugo; Stramare, Roberto; Coran, Alessandro; Grisan, Enrico; Scagliori, Elena; Caso, Francesco; Costa, Luisa; Lunardi, Francesca; Oliviero, Francesca; Bianchi, Fulvia Chieco; Boso, Daniele; Beltrame, Valeria; Vezz'u, Maristella; Cozzi, Luisella; Scarpa, Raffaele; Sacerdoti, David; Punzi, Leonardo; Doria, Andrea; Calabrese, Fiorella; Rubaltelli, Leopoldo Vascular perfusion kinetics by contrast-enhanced ultrasound are related to synovial microvascularity in the joints of psoriatic arthritis. Journal Article Clinical rheumatology, 2015, (Epub ahead of print). BibTeX @article{fiocco2015,
title = {Vascular perfusion kinetics by contrast-enhanced ultrasound are related to synovial microvascularity in the joints of psoriatic arthritis.},
author = { Ugo Fiocco and Roberto Stramare and Alessandro Coran and Enrico Grisan and Elena Scagliori and Francesco Caso and Luisa Costa and Francesca Lunardi and Francesca Oliviero and Fulvia Chieco Bianchi and Daniele Boso and Valeria Beltrame and Maristella Vezz'u and Luisella Cozzi and Raffaele Scarpa and David Sacerdoti and Leonardo Punzi and Andrea Doria and Fiorella Calabrese and Leopoldo Rubaltelli},
year = {2015},
date = {2015-01-01},
journal = {Clinical rheumatology},
note = {Epub ahead of print},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Cozzi, Franco; Raffeiner, Bernd; Beltrame, Valeria; Ciprian, Luca; Coran, Alessandro; Botsios, Constantin; Perissinotto, Egle; Grisan, Enrico; Ramonda, Roberta; Oliviero, Francesca; Stramare, Roberto; Punzi, Leonardo Effects of mud-bath therapy in psoriatic arthritis patients treated with TNF inhibitors. Clinical evaluation and assessment of synovial inflammation by contrast-enhanced ultrasound (CEUS) Journal Article Joint Bone Spine, 82 (2), pp. 104-8, 2015, ISSN: 1778-7254 (Electronic) 1297-319X (Linking), (Epub 2015 Jan 23.). Abstract | Links | BibTeX @article{cozzi2015,
title = {Effects of mud-bath therapy in psoriatic arthritis patients treated with TNF inhibitors. Clinical evaluation and assessment of synovial inflammation by contrast-enhanced ultrasound (CEUS)},
author = { Franco Cozzi and Bernd Raffeiner and Valeria Beltrame and Luca Ciprian and Alessandro Coran and Constantin Botsios and Egle Perissinotto and Enrico Grisan and Roberta Ramonda and Francesca Oliviero and Roberto Stramare and Leonardo Punzi},
doi = {10.1016/j.jbspin.2014.11.002},
issn = {1778-7254 (Electronic) 1297-319X (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Joint Bone Spine},
volume = {82},
number = {2},
pages = {104-8},
abstract = {OBJECTIVES: Despite the efficacy of TNF inhibitors, most patients with psoriatic arthritis maintain a residual synovial inflammation. The main aim of the study was to evaluate the effects of mud-bath therapy on clinical picture of PsA patients treated with TNF inhibitors. The secondary outcome was to assess synovial inflammation in hand joints detected by contrast-enhanced ultrasound. Other aims were to verify the risk of arthritis flare and to evaluate the effects of spa treatment on functional ability and on quality of life. METHODS: Thirty-six patients with psoriatic arthritis, treated in the last 6 months with TNF inhibitors, were enrolled. After 1:1 randomisation, 18 patients (group A) underwent mud-bath therapy (12 mudpacks and 12 thermal baths), maintaining treatment with TNF inhibitors; 18 patients (group B) continued pharmacological therapy alone. CRP, PASI, DAS28, swollen and tender joint count, VAS pain, HAQ and SF-36 were evaluated at baseline (T0) and after 45 days (T1). Synovial inflammation detected by contrast-enhanced ultrasound, analysed by a software system, was also assessed. RESULTS: A significant improvement in PASI (P<0.005), DAS28 (P<0.05), swollen joint count and tender joint count (P<0.001), and HAQ (P<0.001) between T0 and T1 was observed in group A. No patient underwent a flare-up of arthritis. Ultrasound videos demonstrated a significant appearance delay (P<0.05) and faster washout (P<0.02) of contrast dye in group A patients with respect to group B. CONCLUSIONS: These data suggest a decrease of residual synovial inflammation and a beneficial clinical effect of spa therapy in psoriatic arthritis patients treated with TNF inhibitors.},
note = {Epub 2015 Jan 23.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: Despite the efficacy of TNF inhibitors, most patients with psoriatic arthritis maintain a residual synovial inflammation. The main aim of the study was to evaluate the effects of mud-bath therapy on clinical picture of PsA patients treated with TNF inhibitors. The secondary outcome was to assess synovial inflammation in hand joints detected by contrast-enhanced ultrasound. Other aims were to verify the risk of arthritis flare and to evaluate the effects of spa treatment on functional ability and on quality of life. METHODS: Thirty-six patients with psoriatic arthritis, treated in the last 6 months with TNF inhibitors, were enrolled. After 1:1 randomisation, 18 patients (group A) underwent mud-bath therapy (12 mudpacks and 12 thermal baths), maintaining treatment with TNF inhibitors; 18 patients (group B) continued pharmacological therapy alone. CRP, PASI, DAS28, swollen and tender joint count, VAS pain, HAQ and SF-36 were evaluated at baseline (T0) and after 45 days (T1). Synovial inflammation detected by contrast-enhanced ultrasound, analysed by a software system, was also assessed. RESULTS: A significant improvement in PASI (P<0.005), DAS28 (P<0.05), swollen joint count and tender joint count (P<0.001), and HAQ (P<0.001) between T0 and T1 was observed in group A. No patient underwent a flare-up of arthritis. Ultrasound videos demonstrated a significant appearance delay (P<0.05) and faster washout (P<0.02) of contrast dye in group A patients with respect to group B. CONCLUSIONS: These data suggest a decrease of residual synovial inflammation and a beneficial clinical effect of spa therapy in psoriatic arthritis patients treated with TNF inhibitors. |
Calabrese, Massimiliano; Richard, Reynolds; Roberta, Magliozzi; Marco, Castellaro; Aldo, Morra; Antonio, Scalfari; Gabriele, Farina; Chiara, Romualdi; Alberto, Gajofatto; Marco, Pitteri; Donata, Benedetti Maria; Salvatore, Monaco Regional Distribution and Evolution of Gray Matter Damage in Different Populations of Multiple Sclerosis Patients Journal Article PLoS ONE, 10 (8), pp. e0135428, 2015. Abstract | Links | BibTeX @article{plosOne_5yearsMS,
title = {Regional Distribution and Evolution of Gray Matter Damage in Different Populations of Multiple Sclerosis Patients},
author = {Massimiliano Calabrese AND Reynolds Richard AND Magliozzi Roberta AND Castellaro Marco AND Morra Aldo AND Scalfari Antonio AND Farina Gabriele AND Romualdi Chiara AND Gajofatto Alberto AND Pitteri Marco AND Benedetti Maria Donata AND Monaco Salvatore},
url = {http://dx.doi.org/10.1371%2Fjournal.pone.0135428},
doi = {10.1371/journal.pone.0135428 keyword = castellaro},
year = {2015},
date = {2015-01-01},
journal = {PLoS ONE},
volume = {10},
number = {8},
pages = {e0135428},
publisher = {Public Library of Science},
abstract = { Background Both gray-matter (GM) atrophy and lesions occur from the earliest stages of Multiple Sclerosis (MS) and are one of the major determinants of long-term clinical outcomes. Nevertheless, the relationship between focal and diffuse GM damage has not been clarified yet. Here we investigate the regional distribution and temporal evolution of cortical thinning and how it is influenced by the local appearance of new GM lesions at different stages of the disease in different populations of MS patients. Methods We studied twenty MS patients with clinically isolated syndrome (CIS), 27 with early relapsing-remitting MS (RRMS, disease duration <5 years), 29 with late RRMS (disease duration ≥ 5 years) and 20 with secondary-progressive MS (SPMS). The distribution and evolution of regional cortical thickness and GM lesions were assessed during 5-year follow-up. Results The results showed that new lesions appeared more frequently in hippocampus and parahippocampal gyri (9.1%), insula (8.9%), cingulate cortex (8.3%), superior frontal gyrus (8.1%), and cerebellum (6.5%). The aforementioned regions showed the greatest reduction in thickness/volume, although (several) differences were observed across subgroups. The correlation between the appearance of new cortical lesions and cortical thinning was stronger in CIS (r^{2} = 50.0, p<0.001) and in early RRMS (r^{2} = 52.3, p<0.001), compared to late RRMS (r^{2} = 25.5, p<0.001) and SPMS (r^{2} = 6.3},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
<sec id="sec001"> <title>Background</title> <p>Both gray-matter (GM) atrophy and lesions occur from the earliest stages of Multiple Sclerosis (MS) and are one of the major determinants of long-term clinical outcomes. Nevertheless, the relationship between focal and diffuse GM damage has not been clarified yet. Here we investigate the regional distribution and temporal evolution of cortical thinning and how it is influenced by the local appearance of new GM lesions at different stages of the disease in different populations of MS patients.</p> </sec> <sec id="sec002"> <title>Methods</title> <p>We studied twenty MS patients with clinically isolated syndrome (CIS), 27 with early relapsing-remitting MS (RRMS, disease duration <5 years), 29 with late RRMS (disease duration ≥ 5 years) and 20 with secondary-progressive MS (SPMS). The distribution and evolution of regional cortical thickness and GM lesions were assessed during 5-year follow-up.</p> </sec> <sec id="sec003"> <title>Results</title> <p>The results showed that new lesions appeared more frequently in hippocampus and parahippocampal gyri (9.1%), insula (8.9%), cingulate cortex (8.3%), superior frontal gyrus (8.1%), and cerebellum (6.5%). The aforementioned regions showed the greatest reduction in thickness/volume, although (several) differences were observed across subgroups. The correlation between the appearance of new cortical lesions and cortical thinning was stronger in CIS (r2 = 50.0, p<0.001) and in early RRMS (r2 = 52.3, p<0.001), compared to late RRMS (r2 = 25.5, p<0.001) and SPMS (r2 = 6.3 |
Grisan, Enrico; Rizzo, Gaia; Coran, Alessandro; Raffeiner, Bernd; Stramare, Roberto Quantitative ultrasound for diagnosis and assessment of rheumatoid arthritis. Journal Article SPIE Newsroom - Biomedical Optics & Medical Imaging, 2015. BibTeX @article{grisan2015newsroomb,
title = {Quantitative ultrasound for diagnosis and assessment of rheumatoid arthritis.},
author = { Enrico Grisan and Gaia Rizzo and Alessandro Coran and Bernd Raffeiner and Roberto Stramare},
year = {2015},
date = {2015-01-01},
journal = {SPIE Newsroom - Biomedical Optics & Medical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2014
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Castellaro, Marco ; Peruzzo, Denis ; Mehndiratta, Amit ; Pillonetto, Gianluigi ; Petersen, Esben Thade ; Golay, Xavier ; a. Chappell, Michael ; Bertoldo, Alessandra Estimation of arterial arrival time and cerebral blood flow from QUASAR arterial spin labeling using stable spline Journal Article Magn. Reson. Med., 00 (August), pp. n/a–n/a, 2014, ISSN: 07403194, ([Epub ahead of print]). Links | BibTeX @article{Castellaro2014,
title = {Estimation of arterial arrival time and cerebral blood flow from QUASAR arterial spin labeling using stable spline},
author = {Castellaro, Marco and Peruzzo, Denis and Mehndiratta, Amit and Pillonetto, Gianluigi and Petersen, Esben Thade and Golay, Xavier and Chappell, Michael a. and Bertoldo, Alessandra},
url = {http://doi.wiley.com/10.1002/mrm.25525},
doi = {10.1002/mrm.25525},
issn = {07403194},
year = {2014},
date = {2014-01-01},
journal = {Magn. Reson. Med.},
volume = {00},
number = {August},
pages = {n/a--n/a},
note = {[Epub ahead of print]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Bertoldo, Alessandra; Rizzo, Gaia; Veronese, Mattia Deriving physiological information from PET images: from SUV to compartmental modelling Journal Article Clinical and Translational Imaging, 2 (3), pp. 239-251, 2014. Links | BibTeX @article{Bertoldo2014,
title = {Deriving physiological information from PET images: from SUV to compartmental modelling},
author = { Alessandra Bertoldo and Gaia Rizzo and Mattia Veronese},
url = {http://dx.doi.org/10.1007/s40336-014-0067-x},
doi = {10.1007/s40336-014-0067-x},
year = {2014},
date = {2014-01-01},
journal = {Clinical and Translational Imaging},
volume = {2},
number = {3},
pages = {239-251},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Rizzo, Gaia; Veronese, Mattia; Heckemann, Rolf A; Selvaraj, Sudhakar; Howes, Oliver D; Hammers, Alexander; Turkheimer, Federico E; Bertoldo, Alessandra The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study Journal Article J Cereb Blood Flow Metab, 34 (5), pp. 827-35, 2014, ISSN: 1559-7016 (Electronic) 0271-678X (Linking). Links | BibTeX @article{Rizzo2014a,
title = {The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study},
author = { Gaia Rizzo and Mattia Veronese and Rolf A Heckemann and Sudhakar Selvaraj and Oliver D Howes and Alexander Hammers and Federico E. Turkheimer and Alessandra Bertoldo},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24496175},
doi = {10.1038/jcbfm.2014.21},
issn = {1559-7016 (Electronic) 0271-678X (Linking)},
year = {2014},
date = {2014-01-01},
journal = {J Cereb Blood Flow Metab},
volume = {34},
number = {5},
pages = {827-35},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Rizzo, Gaia; Veronese, Mattia; Tonietto, Matteo; Fregonara, Paolo Zanotti; Turkheimer, Federico E; Bertoldo, Alessandra Kinetic modeling without accounting for the vascular component impairs the quantification of [11C]PBR28 brain PET data Journal Article J Cereb Blood Flow Metab, 34 (6), pp. 1060–1069, 2014. Links | BibTeX @article{Rizzo2014b,
title = {Kinetic modeling without accounting for the vascular component impairs the quantification of [11C]PBR28 brain PET data},
author = { Gaia Rizzo and Mattia Veronese and Matteo Tonietto and Paolo Zanotti Fregonara and Federico E. Turkheimer and Alessandra Bertoldo },
url = {http://www.ncbi.nlm.nih.gov/pubmed/24667911},
doi = {doi:10.1038/jcbfm.2014.55},
year = {2014},
date = {2014-01-01},
journal = {J Cereb Blood Flow Metab},
volume = {34},
number = {6},
pages = {1060–1069},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Veronese, Mattia; Rizzo, Gaia; Aboagye, Eric; Bertoldo, Alessandra Parametric imaging of 18f-fluro-3-deoxy-3-l-fluorothymidine PET data to investigate tumor heterogeneity Journal Article European Journal of Nuclear Medicine and Molecular Imaging, 41 (9), pp. 1781-1792, 2014, ISSN: 1619-7089. Abstract | Links | BibTeX @article{Veronese2014,
title = {Parametric imaging of 18f-fluro-3-deoxy-3-l-fluorothymidine PET data to investigate tumor heterogeneity},
author = { Mattia Veronese and Gaia Rizzo and Eric Aboagye and Alessandra Bertoldo},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24705620},
doi = {10.1007/s00259-014-2757-z},
issn = {1619-7089},
year = {2014},
date = {2014-01-01},
journal = {European Journal of Nuclear Medicine and Molecular Imaging},
volume = {41},
number = {9},
pages = {1781-1792},
abstract = {PURPOSE: [(18)F]Fluoro-3'-deoxy-3'-L-fluorothymidine ([(18)F]FLT) is a tissue proliferation marker which has been widely validated as a tumour-specific imaging tracer for PET. [(18)F]FLT uptake in breast cancer is generally quantified at the region level or through first-order statistical descriptors (mean or maximum value), approaches that ignore the known complexity and heterogeneity of cancer tissues. Our aims were: (1) to validate a robust and reproducible voxel-wise approach to the quantification of [(18)F]FLT PET data in breast cancer patients, and (2) to exploit the entire distribution of the [(18)F]FLT retention estimates and their variability in the tumour region for the prediction of early treatment response. METHODS: The dataset was derived from 15 patients with stage II-IV breast cancer, scanned twice before chemotherapy and once 1 week after therapy. Using RECIST criteria (after 60 days) nine patients were categorized as responders or nonresponders to treatment. Kinetic modelling (compartmental modelling, Patlak analysis and spectral analysis with iterative filter), tissue-to-plasma ratio and standardized uptake value were applied at the voxel level. Test-retest estimates were used to assess reproducibility and reliability of the [(18)F]FLT uptake values before and after therapy for responder/nonresponder prediction. RESULTS: All the methods provided a measure of [(18)F]FLT uptake that was reliable and reproducible with ICC >0.94. Moreover, a very strong correlation was found among the methods (R (2) > 0.81). All the methods provided a limited number of outliers (<20 % in tumour), with the exception of compartmental modelling (>25 %) which was therefore excluded from the prediction analysis. Differences between before and after therapy in mean voxel-wise uptake in tumour did not allow a complete responder/nonresponder classification. In contrast, considering the full estimate distributions within the tumour (changes in median and mode between before and after therapy) improved therapy response for all the analysed methods. CONCLUSION: We showed that kinetic modelling (Patlak and spectral analysis with iterative filter) applied voxel-wise allows appropriate [(18)F]FLT uptake estimation in breast cancer with good reproducibility. Notably, this study indicated that a more comprehensive statistical investigation could improve tumour characterization and prediction of treatment response.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: [(18)F]Fluoro-3'-deoxy-3'-L-fluorothymidine ([(18)F]FLT) is a tissue proliferation marker which has been widely validated as a tumour-specific imaging tracer for PET. [(18)F]FLT uptake in breast cancer is generally quantified at the region level or through first-order statistical descriptors (mean or maximum value), approaches that ignore the known complexity and heterogeneity of cancer tissues. Our aims were: (1) to validate a robust and reproducible voxel-wise approach to the quantification of [(18)F]FLT PET data in breast cancer patients, and (2) to exploit the entire distribution of the [(18)F]FLT retention estimates and their variability in the tumour region for the prediction of early treatment response. METHODS: The dataset was derived from 15 patients with stage II-IV breast cancer, scanned twice before chemotherapy and once 1 week after therapy. Using RECIST criteria (after 60 days) nine patients were categorized as responders or nonresponders to treatment. Kinetic modelling (compartmental modelling, Patlak analysis and spectral analysis with iterative filter), tissue-to-plasma ratio and standardized uptake value were applied at the voxel level. Test-retest estimates were used to assess reproducibility and reliability of the [(18)F]FLT uptake values before and after therapy for responder/nonresponder prediction. RESULTS: All the methods provided a measure of [(18)F]FLT uptake that was reliable and reproducible with ICC >0.94. Moreover, a very strong correlation was found among the methods (R (2) > 0.81). All the methods provided a limited number of outliers (<20 % in tumour), with the exception of compartmental modelling (>25 %) which was therefore excluded from the prediction analysis. Differences between before and after therapy in mean voxel-wise uptake in tumour did not allow a complete responder/nonresponder classification. In contrast, considering the full estimate distributions within the tumour (changes in median and mode between before and after therapy) improved therapy response for all the analysed methods. CONCLUSION: We showed that kinetic modelling (Patlak and spectral analysis with iterative filter) applied voxel-wise allows appropriate [(18)F]FLT uptake estimation in breast cancer with good reproducibility. Notably, this study indicated that a more comprehensive statistical investigation could improve tumour characterization and prediction of treatment response. |
Zanotti-Fregonara, Paolo; Leroy, Claire; Rizzo, Gaia; Roumenov, Dimitri; Trichard, Christian; Martinot, Jean-Luc; Bottlaender, Michel Imaging of monoamine oxidase-A in the human brain with [11C]befloxatone: quantification strategies and correlation with mRNA transcription maps Journal Article Nucl Med Commun, 35 (12), pp. 1254-61, 2014, ISSN: 0143-3636. Abstract | Links | BibTeX @article{Zanotti-Fregonara2014,
title = {Imaging of monoamine oxidase-A in the human brain with [11C]befloxatone: quantification strategies and correlation with mRNA transcription maps},
author = { Paolo Zanotti-Fregonara and Claire Leroy and Gaia Rizzo and Dimitri Roumenov and Christian Trichard and Jean-Luc Martinot and Michel Bottlaender},
doi = {10.1097/mnm.0000000000000196},
issn = {0143-3636},
year = {2014},
date = {2014-01-01},
journal = {Nucl Med Commun},
volume = {35},
number = {12},
pages = {1254-61},
abstract = {INTRODUCTION: [C]Befloxatone is a highly specific, reversible, and selective radioligand for brain PET imaging of monoamine oxidase-A and can be quantified by a two-tissue compartment model (2TCM) and an arterial input function. The aims of the present study were the following: (a) to assess whether in-vivo protein concentration, as measured by [C]befloxatone total distribution volume (VT), is correlated with post-mortem mRNA expression; (b) to replicate in a population of tobacco smokers the results of a recent study on healthy nonsmokers, which showed that spectral analysis (SA) provides a highly accurate estimation of [C]befloxatone-VT at the voxel level; and (c) to validate the use of an input function that would not require arterial sampling. MATERIALS AND METHODS: Healthy male nonsmokers (n=7) and smokers (n=8) were imaged with PET and [C]befloxatone. Binding was quantified at the regional and voxel level with the Logan plot, multilinear analysis (MA1), and SA. VT values were compared with the reference values obtained by 2TCM at the regional level. [C]Befloxatone binding was compared with mRNA transcription maps from the Allen Human Brain Atlas. A less-invasive input function was obtained with a population-based input function (PBIF) scaled with arterialized venous samples. RESULTS: mRNA expression was highly correlated with in-vivo 2TCM-VT values both for nonsmokers (R=0.873; P<0.0001) and for smokers (R=0.851; P<0.0001). At the regional level, both Logan and MA1 showed a moderate negative bias (-5 to -10%) compared with the reference VT values. With the exception of a single outlying individual, SA showed little bias and variability (+4.4+/-3.5%). Although variability was higher than at the regional level, SA provided the most accurate VT estimations at the voxel level: all but one participant had an error of less than 20%. Parametric Logan and MA1 analyses gave highly biased or unusable results. PBIF provided good results in all participants in whom the arterialization of venous blood was successful (all errors of about 10% or less). CONCLUSION: [C]Befloxatone binding is strongly correlated with the values of mRNA transcription measured in post-mortem brains. At the voxel level, SA is the best available choice for [C]befloxatone quantification, although a higher variability must be expected. When an arterial input function is not technically feasible, a PBIF scaled with arterialized venous samples may provide an acceptable alternative, provided an optimal arterialization can be achieved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: [C]Befloxatone is a highly specific, reversible, and selective radioligand for brain PET imaging of monoamine oxidase-A and can be quantified by a two-tissue compartment model (2TCM) and an arterial input function. The aims of the present study were the following: (a) to assess whether in-vivo protein concentration, as measured by [C]befloxatone total distribution volume (VT), is correlated with post-mortem mRNA expression; (b) to replicate in a population of tobacco smokers the results of a recent study on healthy nonsmokers, which showed that spectral analysis (SA) provides a highly accurate estimation of [C]befloxatone-VT at the voxel level; and (c) to validate the use of an input function that would not require arterial sampling. MATERIALS AND METHODS: Healthy male nonsmokers (n=7) and smokers (n=8) were imaged with PET and [C]befloxatone. Binding was quantified at the regional and voxel level with the Logan plot, multilinear analysis (MA1), and SA. VT values were compared with the reference values obtained by 2TCM at the regional level. [C]Befloxatone binding was compared with mRNA transcription maps from the Allen Human Brain Atlas. A less-invasive input function was obtained with a population-based input function (PBIF) scaled with arterialized venous samples. RESULTS: mRNA expression was highly correlated with in-vivo 2TCM-VT values both for nonsmokers (R=0.873; P<0.0001) and for smokers (R=0.851; P<0.0001). At the regional level, both Logan and MA1 showed a moderate negative bias (-5 to -10%) compared with the reference VT values. With the exception of a single outlying individual, SA showed little bias and variability (+4.4+/-3.5%). Although variability was higher than at the regional level, SA provided the most accurate VT estimations at the voxel level: all but one participant had an error of less than 20%. Parametric Logan and MA1 analyses gave highly biased or unusable results. PBIF provided good results in all participants in whom the arterialization of venous blood was successful (all errors of about 10% or less). CONCLUSION: [C]Befloxatone binding is strongly correlated with the values of mRNA transcription measured in post-mortem brains. At the voxel level, SA is the best available choice for [C]befloxatone quantification, although a higher variability must be expected. When an arterial input function is not technically feasible, a PBIF scaled with arterialized venous samples may provide an acceptable alternative, provided an optimal arterialization can be achieved. |
Veronese, Elisa; Tarroni, Giacomo; Visentin, Silvia; Cosmi, Erich; Linguraru, Marius George; Grisan, Enrico Estimation of prenatal aorta intima-media thickness from ultrasound examination Journal Article Physics in medicine and biology, 59 (21), pp. 6355–71, 2014, ISSN: 1361-6560. Abstract | Links | BibTeX @article{Veronese2014b,
title = {Estimation of prenatal aorta intima-media thickness from ultrasound examination},
author = { Elisa Veronese and Giacomo Tarroni and Silvia Visentin and Erich Cosmi and Marius George Linguraru and Enrico Grisan},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25295390},
doi = {10.1088/0022-3727/59/21/6355},
issn = {1361-6560},
year = {2014},
date = {2014-01-01},
journal = {Physics in medicine and biology},
volume = {59},
number = {21},
pages = {6355--71},
abstract = {Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data.The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed.Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%).The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data.The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed.Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%).The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT. |
Visentin, Silvia; Grumolato, Francesca; Nardelli, Giovanni Battista; Camillo, Barbara Di; Grisan, Enrico; Cosmi, Erich Early origins of adult disease: Low birth weight and vascular remodeling Journal Article Atherosclerosis, 237 (2), pp. 391-399, 2014. Links | BibTeX @article{Visentin2014391,
title = {Early origins of adult disease: Low birth weight and vascular remodeling},
author = { Silvia Visentin and Francesca Grumolato and Giovanni Battista Nardelli and Barbara Di Camillo and Enrico Grisan and Erich Cosmi},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84908389409&partnerID=40&md5=d4ab97ba325177d6dde58639231bbfa1},
doi = {10.1016/j.atherosclerosis.2014.09.027},
year = {2014},
date = {2014-01-01},
journal = {Atherosclerosis},
volume = {237},
number = {2},
pages = {391-399},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Stramare, Roberto; Coran, Alessandro; Faccinetto, Alex; Costantini, Giulia; Bernardi, Livio; Botsios, Costantino; Perissinotto, Egle; Grisan, Enrico; Beltrame, Valeria; Raffeiner, Bernd MR and CEUS monitoring of patients with severe rheumatoid arthritis treated with biological agents: A preliminary study Journal Article Radiologia Medica, 119 (6), pp. 422-431, 2014. Links | BibTeX @article{Stramare2014422,
title = {MR and CEUS monitoring of patients with severe rheumatoid arthritis treated with biological agents: A preliminary study},
author = { Roberto Stramare and Alessandro Coran and Alex Faccinetto and Giulia Costantini and Livio Bernardi and Costantino Botsios and Egle Perissinotto and Enrico Grisan and Valeria Beltrame and Bernd Raffeiner},
doi = {10.1007/s11547-013-0369-5},
year = {2014},
date = {2014-01-01},
journal = {Radiologia Medica},
volume = {119},
number = {6},
pages = {422-431},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ferrari, Giulio; Grisan, Enrico; Scarpa, Fabio; Fazio, Raffaella; Comola, Mauro; Quattrini, Angelo; Comi, Giancarlo; Rama, Paolo; Riva, Nilo Corneal confocal microscopy reveals trigeminal small sensory fiber neuropathy in amyotrophic lateral sclerosis Journal Article Frontiers in Aging Neuroscience, 6 (OCT), 2014. Links | BibTeX @article{Ferrari2014,
title = {Corneal confocal microscopy reveals trigeminal small sensory fiber neuropathy in amyotrophic lateral sclerosis},
author = { Giulio Ferrari and Enrico Grisan and Fabio Scarpa and Raffaella Fazio and Mauro Comola and Angelo Quattrini and Giancarlo Comi and Paolo Rama and Nilo Riva},
doi = {10.3389/fnagi.2014.00278},
year = {2014},
date = {2014-01-01},
journal = {Frontiers in Aging Neuroscience},
volume = {6},
number = {OCT},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Rusu, Cristian; Morisi, Rita; Boschetto, Davide; Dharmakumar, Rohan; Tsaftaris, Sotirios A Synthetic Generation of Myocardial Blood-Oxygen-Level-Đependent MRI Time Series via Structural Sparse Decomposition Modeling Journal Article IEEE Trans Med Imaging., 33 (7), pp. 1422-33, 2014. BibTeX @article{greco0,
title = {Synthetic Generation of Myocardial Blood-Oxygen-Level-Đependent MRI Time Series via Structural Sparse Decomposition Modeling},
author = { Cristian Rusu and Rita Morisi and Davide Boschetto and Rohan Dharmakumar and Sotirios A. Tsaftaris},
year = {2014},
date = {2014-01-01},
journal = {IEEE Trans Med Imaging.},
volume = {33},
number = {7},
pages = {1422-33},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Grecchi, E; Doyle, O M; Bertoldo, A; Pavese, N; Turkheimer, F E Brain shaving: Adaptive detection for brain PET data Journal Article Physics in Medicine and Biology, 59 (10), pp. 2517-2534, 2014. Links | BibTeX @article{Grecchi20142517,
title = {Brain shaving: Adaptive detection for brain PET data},
author = { E. Grecchi and O.M. Doyle and A. Bertoldo and N. Pavese and F.E. Turkheimer},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84899653436&partnerID=40&md5=4030661423d865b6a78b7e1293aebaa5},
doi = {10.1088/0031-9155/59/10/2517},
year = {2014},
date = {2014-01-01},
journal = {Physics in Medicine and Biology},
volume = {59},
number = {10},
pages = {2517-2534},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Din, Del S; Bertoldo, A; Sawacha, Z; Jonsdottir, J; Rabuffetti, M; Cobelli, C; Ferrarin, M Assessment of biofeedback rehabilitation in post-stroke patients combining fMRI and gait analysis: A case study Journal Article Journal of NeuroEngineering and Rehabilitation, 11 (1), 2014. Links | BibTeX @article{DelDin2014,
title = {Assessment of biofeedback rehabilitation in post-stroke patients combining fMRI and gait analysis: A case study},
author = { S. Del Din and A. Bertoldo and Z. Sawacha and J. Jonsdottir and M. Rabuffetti and C. Cobelli and M. Ferrarin},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84906534328&partnerID=40&md5=714ab2c2cc1449d3b03310d1edde0195},
doi = {10.1186/1743-0003-11-53},
year = {2014},
date = {2014-01-01},
journal = {Journal of NeuroEngineering and Rehabilitation},
volume = {11},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Utzschneider, K M; Largajolli, A; Bertoldo, A; Marcovina, S; Nelson, J E; Yeh, M M; Kowdley, K V; Kahn, S E Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women Journal Article Journal of Diabetes and its Complications, 28 (2), pp. 177-184, 2014. Links | BibTeX @article{Utzschneider2014177,
title = {Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women},
author = { K.M. Utzschneider and A. Largajolli and A. Bertoldo and S. Marcovina and J.E. Nelson and M.M. Yeh and K.V. Kowdley and S.E. Kahn},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84896708656&partnerID=40&md5=465b88ef670ed0c52e2e6b5b81e8e16c},
doi = {10.1016/j.jdiacomp.2013.11.007},
year = {2014},
date = {2014-01-01},
journal = {Journal of Diabetes and its Complications},
volume = {28},
number = {2},
pages = {177-184},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Goodpaster, B H; Bertoldo, A; Ng, J M; Azuma, K; Pencek, R R; Kelley, C; Price, J C; Cobelli, C; Kelley, D E Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle insulin resistance in obesity and type 2 diabetes: Studies with dynamic pet imaging Journal Article Diabetes, 63 (3), pp. 1058-1068, 2014. Links | BibTeX @article{Goodpaster20141058,
title = {Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle insulin resistance in obesity and type 2 diabetes: Studies with dynamic pet imaging},
author = { B.H. Goodpaster and A. Bertoldo and J.M. Ng and K. Azuma and R.R. Pencek and C. Kelley and J.C. Price and C. Cobelli and D.E. Kelley},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84894484960&partnerID=40&md5=d5889575b38caeea59525097ac803096},
doi = {10.2337/db13-1249},
year = {2014},
date = {2014-01-01},
journal = {Diabetes},
volume = {63},
number = {3},
pages = {1058-1068},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Storti, S F; Formaggio, E; Moretto, D; Bertoldo, A; Pizzini, F B; Beltramello, A; Fiaschi, A; Toffolo, G M; Manganotti, P Effect of voluntary repetitive long-lasting muscle contraction activity on the BOLD signal as assessed by optimal hemodynamic response function Journal Article Magnetic Resonance Materials in Physics, Biology and Medicine, 27 (2), pp. 171-184, 2014. Links | BibTeX @article{Storti2014171,
title = {Effect of voluntary repetitive long-lasting muscle contraction activity on the BOLD signal as assessed by optimal hemodynamic response function},
author = { S.F. Storti and E. Formaggio and D. Moretto and A. Bertoldo and F.B. Pizzini and A. Beltramello and A. Fiaschi and G.M. Toffolo and P. Manganotti},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84898057284&partnerID=40&md5=a4dac712ce9403b9b06adf44cfcd1c7a},
doi = {10.1007/s10334-013-0401-8},
year = {2014},
date = {2014-01-01},
journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
volume = {27},
number = {2},
pages = {171-184},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Cobelli, C; Man, C D; Pedersen, M G; Bertoldo, A; Toffolo, G Advancing our understanding of the glucose system via modeling: A perspective Journal Article IEEE Transactions on Biomedical Engineering, 61 (5), pp. 1577-1592, 2014. Links | BibTeX @article{Cobelli20141577,
title = {Advancing our understanding of the glucose system via modeling: A perspective},
author = { C. Cobelli and C.D. Man and M.G. Pedersen and A. Bertoldo and G. Toffolo},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84899686460&partnerID=40&md5=5ebabeb5d6ce2bfaafee8f521a3dd876},
doi = {10.1109/TBME.2014.2310514},
year = {2014},
date = {2014-01-01},
journal = {IEEE Transactions on Biomedical Engineering},
volume = {61},
number = {5},
pages = {1577-1592},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ng, J M; Bertoldo, A; Minhas, D S; Helbling, N L; Coen, P M; Price, J C; Cobelli, C; Kelley, D E; Goodpaster, B H Dynamic PET imaging reveals heterogeneity of skeletal muscle insulin resistance Journal Article Journal of Clinical Endocrinology and Metabolism, 99 (1), pp. E102-E106, 2014. Links | BibTeX @article{Ng2014E102,
title = {Dynamic PET imaging reveals heterogeneity of skeletal muscle insulin resistance},
author = { J.M. Ng and A. Bertoldo and D.S. Minhas and N.L. Helbling and P.M. Coen and J.C. Price and C. Cobelli and D.E. Kelley and B.H. Goodpaster},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84892161669&partnerID=40&md5=070c9782830ae74190b2951272e35788},
doi = {10.1210/jc.2013-2095},
year = {2014},
date = {2014-01-01},
journal = {Journal of Clinical Endocrinology and Metabolism},
volume = {99},
number = {1},
pages = {E102-E106},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2013
|
Veronese, M; Gunn, R N; Zamuner, S; Bertoldo, A A non-linear mixed effect modelling approach for metabolite correction of the arterial input function in PET studies Journal Article NeuroImage, 66 , pp. 611-622, 2013. Links | BibTeX @article{Veronese2013611,
title = {A non-linear mixed effect modelling approach for metabolite correction of the arterial input function in PET studies},
author = { M. Veronese and R.N. Gunn and S. Zamuner and A. Bertoldo},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84870314852&partnerID=40&md5=09171bf0fea153b28dc9bc944bfa68f6},
doi = {10.1016/j.neuroimage.2012.10.048},
year = {2013},
date = {2013-01-01},
journal = {NeuroImage},
volume = {66},
pages = {611-622},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Galazzo, I B; Storti, S F; Formaggio, E; Pizzini, F B; Fiaschi, A; Beltramello, A; Bertoldo, A; Manganotti, P Investigation of brain hemodynamic changes induced by active and passive movements: A combined arterial spin labeling-bold fMRI study Journal Article Journal of Magnetic Resonance Imaging, 40 (4), pp. 937-948, 2013. Links | BibTeX @article{Galazzo2013937,
title = {Investigation of brain hemodynamic changes induced by active and passive movements: A combined arterial spin labeling-bold fMRI study},
author = { I.B. Galazzo and S.F. Storti and E. Formaggio and F.B. Pizzini and A. Fiaschi and A. Beltramello and A. Bertoldo and P. Manganotti},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84927799131&partnerID=40&md5=38f355483b6733896f3ce690fa0bb121},
doi = {10.1002/jmri.24432},
year = {2013},
date = {2013-01-01},
journal = {Journal of Magnetic Resonance Imaging},
volume = {40},
number = {4},
pages = {937-948},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Peruzzo, Denis ; Castellaro, Marco ; Calabrese, Massimiliano ; Veronese, Elisa ; Rinaldi, Francesca ; Bernardi, Valentina ; Favaretto, Alice ; Gallo, Paolo ; Bertoldo, Alessandra Heterogeneity of cortical lesions in multiple sclerosis: an MRI perfusion study. Journal Article J. Cereb. Blood Flow Metab., 33 (3), pp. 457–63, 2013, ISSN: 1559-7016. Abstract | Links | BibTeX @article{Peruzzo2013,
title = {Heterogeneity of cortical lesions in multiple sclerosis: an MRI perfusion study.},
author = {Peruzzo, Denis and Castellaro, Marco and Calabrese, Massimiliano and Veronese, Elisa and Rinaldi, Francesca and Bernardi, Valentina and Favaretto, Alice and Gallo, Paolo and Bertoldo, Alessandra},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23250108},
issn = {1559-7016},
year = {2013},
date = {2013-01-01},
journal = {J. Cereb. Blood Flow Metab.},
volume = {33},
number = {3},
pages = {457--63},
publisher = {Nature Publishing Group},
abstract = {In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis. |
Rizzo, Gaia; Turkheimer, Federico E; Bertoldo, Alessandra Multi-scale hierarchical approach for parametric mapping: assessment on multi-compartmental models Journal Article Neuroimage, 67 , pp. 344-53, 2013, ISSN: 1095-9572 (Electronic) 1053-8119 (Linking). Abstract | Links | BibTeX @article{Rizzo2013a,
title = {Multi-scale hierarchical approach for parametric mapping: assessment on multi-compartmental models},
author = { Gaia Rizzo and Federico E. Turkheimer and Alessandra Bertoldo},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23220428},
doi = {10.1016/j.neuroimage.2012.11.045},
issn = {1095-9572 (Electronic) 1053-8119 (Linking)},
year = {2013},
date = {2013-01-01},
journal = {Neuroimage},
volume = {67},
pages = {344-53},
abstract = {This paper investigates a new hierarchical method to apply basis function to mono- and multi-compartmental models (Hierarchical-Basis Function Method, H-BFM) at a voxel level. This method identifies the parameters of the compartmental model in its nonlinearized version, integrating information derived at the region of interest (ROI) level by segmenting the cerebral volume based on anatomical definition or functional clustering. We present the results obtained by using a two tissue-four rate constant model with two different tracers ([(11)C]FLB457 and [carbonyl-(11)C]WAY100635), one of the most complex models used in receptor studies, especially at the voxel level. H-BFM is robust and its application on both [(11)C]FLB457 and [carbonyl-(11)C]WAY100635 allows accurate and precise parameter estimates, good quality parametric maps and a low percentage of voxels out of physiological bound (<8%). The computational time depends on the number of basis functions selected and can be compatible with clinical use (~6h for a single subject analysis). The novel method is a robust approach for PET quantification by using compartmental modeling at the voxel level. In particular, different from other proposed approaches, this method can also be used when the linearization of the model is not appropriate. We expect that applying it to clinical data will generate reliable parametric maps.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This paper investigates a new hierarchical method to apply basis function to mono- and multi-compartmental models (Hierarchical-Basis Function Method, H-BFM) at a voxel level. This method identifies the parameters of the compartmental model in its nonlinearized version, integrating information derived at the region of interest (ROI) level by segmenting the cerebral volume based on anatomical definition or functional clustering. We present the results obtained by using a two tissue-four rate constant model with two different tracers ([(11)C]FLB457 and [carbonyl-(11)C]WAY100635), one of the most complex models used in receptor studies, especially at the voxel level. H-BFM is robust and its application on both [(11)C]FLB457 and [carbonyl-(11)C]WAY100635 allows accurate and precise parameter estimates, good quality parametric maps and a low percentage of voxels out of physiological bound (<8%). The computational time depends on the number of basis functions selected and can be compatible with clinical use (~6h for a single subject analysis). The novel method is a robust approach for PET quantification by using compartmental modeling at the voxel level. In particular, different from other proposed approaches, this method can also be used when the linearization of the model is not appropriate. We expect that applying it to clinical data will generate reliable parametric maps. |
Rizzo, Gaia; Veronese, Mattia; Zanotti-Fregonara, Paolo; Bertoldo, Alessandra Voxelwise quantification of [(11)C](R)-rolipram PET data: a comparison between model-based and data-driven methods Journal Article J Cereb Blood Flow Metab, 33 (7), pp. 1032-40, 2013, ISSN: 0271-678x. Links | BibTeX @article{Rizzo2013b,
title = {Voxelwise quantification of [(11)C](R)-rolipram PET data: a comparison between model-based and data-driven methods},
author = { Gaia Rizzo and Mattia Veronese and Paolo Zanotti-Fregonara and Alessandra Bertoldo},
doi = {10.1038/jcbfm.2013.43},
issn = {0271-678x},
year = {2013},
date = {2013-01-01},
journal = {J Cereb Blood Flow Metab},
volume = {33},
number = {7},
pages = {1032-40},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Veronese, Mattia; Rizzo, Gaia; Turkheimer, Federico E; Bertoldo, Alessandra SAKE: A new quantification tool for positron emission tomography studies Journal Article Comput Methods Programs Biomed, 111 (1), pp. 199-213, 2013, ISSN: 1872-7565 (Electronic) 0169-2607 (Linking). Links | BibTeX @article{Veronese2013,
title = {SAKE: A new quantification tool for positron emission tomography studies},
author = { Mattia Veronese and Gaia Rizzo and Federico E. Turkheimer and Alessandra Bertoldo},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23611334},
doi = {10.1016/j.cmpb.2013.03.016},
issn = {1872-7565 (Electronic) 0169-2607 (Linking)},
year = {2013},
date = {2013-01-01},
journal = {Comput Methods Programs Biomed},
volume = {111},
number = {1},
pages = {199-213},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2017
|
Corain, L; Peruffo, A; Grisan, E; Salmaso, L Multi-Aspect Nonparametric Testing and Ranking on Mixed Distributions with Application to Image Analysis in Neuroanatomy Inproceedings Proceedings of the Joint Statistical Meetings 2017, 2017. BibTeX @inproceedings{corain_JSM_2017,
title = {Multi-Aspect Nonparametric Testing and Ranking on Mixed Distributions with Application to Image Analysis in Neuroanatomy},
author = {L. Corain and A. Peruffo and E. Grisan and L. Salmaso},
year = {2017},
date = {2017-08-03},
booktitle = {Proceedings of the Joint Statistical Meetings 2017},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Peruffo, A; Corain, L; Graïc, J-M; Grisan, E A quantitative approach to measure and rank the brain cytoarchitecture: the cerebellar case study Inproceedings Proceedings of the XI Congresso Nazionale AMV Roma, 2017. BibTeX @inproceedings{peruffo_AMV_2017,
title = {A quantitative approach to measure and rank the brain cytoarchitecture: the cerebellar case study},
author = {A. Peruffo and L. Corain and J-M Graïc and E. Grisan},
year = {2017},
date = {2017-05-25},
booktitle = {Proceedings of the XI Congresso Nazionale AMV Roma},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Grisan, E; Rizzo, G; Tonietto, M; Coran, A; Raffeiner, B; Scanu, A; Martini, V; Stramare, R; Fiocco, U From macro to nano: linking quantitative CEUS perfusion parameters to CD4+ T cells subtypes in spondyloarthtitis Inproceedings Proceedings of ISBI, IEEE International Symposium on Biomedical Imaging, 2017. BibTeX @inproceedings{grisan_ISBI_2017,
title = {From macro to nano: linking quantitative CEUS perfusion parameters to CD4+ T cells subtypes in spondyloarthtitis},
author = {E. Grisan and G. Rizzo and M. Tonietto and A. Coran and B. Raffeiner and A. Scanu and V. Martini and R. Stramare and U. Fiocco},
year = {2017},
date = {2017-04-17},
booktitle = {Proceedings of ISBI, IEEE International Symposium on Biomedical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Palombit, A; Castellaro, M; Calabrese, M; Romualdi, C; Pizzini, F; Montemezzi, S; Grisan, E; Bertoldo, A Cortical thickness variability in multiple sclerosis: the role of lesion segmentation and filling Inproceedings Proceedings of ISBI, IEEE International Symposium on Biomedical Imaging, IEEE, 2017. BibTeX @inproceedings{palombit_ISBI_2017,
title = {Cortical thickness variability in multiple sclerosis: the role of lesion segmentation and filling},
author = {A. Palombit and M. Castellaro and M. Calabrese and C. Romualdi and F. Pizzini and S. Montemezzi and E. Grisan and A. Bertoldo},
year = {2017},
date = {2017-04-16},
booktitle = {Proceedings of ISBI, IEEE International Symposium on Biomedical Imaging},
publisher = {IEEE},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Rizzo, G; Tonietto, M; Castellaro, M; Coran, A; Raffeiner, B; Fiocco, U; Stramare, R; Grisan, E Improving the quantification of contrast enhanced ultrasound using a Bayesian approach Conference SPIE Conference on Medical Imaging, 2017. BibTeX @conference{rizzo_spie_2017_VB,
title = {Improving the quantification of contrast enhanced ultrasound using a Bayesian approach},
author = {G. Rizzo and M. Tonietto and M. Castellaro and A. Coran and B. Raffeiner and U. Fiocco and R. Stramare and E. Grisan},
year = {2017},
date = {2017-02-15},
booktitle = {SPIE Conference on Medical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rizzo, G; Tonietto, M; Castellaro, M; Coran, A; Raffeiner, B; Fiocco, U; Stramare, R; Grisan, E Detection of a slow-flow component in contrast-enhanced ultrasound of the synovia for the differential diagnosis of arthritis Conference SPIE Conference on Medical Imaging, 2017. BibTeX @conference{rizzo_spie_2017_slow,
title = {Detection of a slow-flow component in contrast-enhanced ultrasound of the synovia for the differential diagnosis of arthritis},
author = {G. Rizzo and M. Tonietto and M. Castellaro and A. Coran and B. Raffeiner and U. Fiocco and R. Stramare and E. Grisan},
year = {2017},
date = {2017-02-15},
booktitle = {SPIE Conference on Medical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Grisan, E Boosted learned kernels for data-driven vesselness measure Conference SPIE Conference on Medical Imaging, 2017. BibTeX @conference{grisan_SPIE2017_vesselness,
title = {Boosted learned kernels for data-driven vesselness measure},
author = {E. Grisan},
year = {2017},
date = {2017-02-14},
booktitle = {SPIE Conference on Medical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Grisan, E; Boschetto, D Superpixel-based classification of gastric chromoendoscopy images Conference SPIE Conference on Medical Imaging, 2017. BibTeX @conference{grisan_SPIE2017_chromoendo,
title = {Superpixel-based classification of gastric chromoendoscopy images},
author = {E. Grisan and D. Boschetto},
year = {2017},
date = {2017-02-14},
booktitle = {SPIE Conference on Medical Imaging},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
2016
|
Vadori, V; Grisan, E; Rossi, M Biomedical Signal Compression With Time- And Subject-Adaptive Dictionary For Wearable Devices Conference IEEE International Workshop on Machine Learning for Signal Processing, 2016. BibTeX @conference{vadori_mlsp_2016,
title = {Biomedical Signal Compression With Time- And Subject-Adaptive Dictionary For Wearable Devices},
author = {V. Vadori and E. Grisan and M. Rossi},
year = {2016},
date = {2016-09-13},
booktitle = {IEEE International Workshop on Machine Learning for Signal Processing},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rizzo, G; Castellaro, M; Tonietto, M; Veronese, M; Turkheimer, F E; Chappell, M A; Bertoldo, A Parametric imaging of brain PET data using a Variational Bayesian inference approach Conference Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016), 2016, (oral). BibTeX @conference{Rizzo2016VB,
title = {Parametric imaging of brain PET data using a Variational Bayesian inference approach},
author = {Rizzo, G. and Castellaro, M. and Tonietto, M. and Veronese, M. and Turkheimer, F.E. and Chappell, M.A. and Bertoldo, A.},
year = {2016},
date = {2016-07-13},
booktitle = {Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016)},
note = {oral},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Veronese, M; Zanotti-Fregonara, P; Rizzo, G; Bertoldo, A; Innis, R B; Turkheimer, F E The genomic plot: a new method for measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade Conference Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016), Boston (MA, USA), 13-17 July 2016 2016, (oral). BibTeX @conference{Veronese2016NRM,
title = {The genomic plot: a new method for measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade},
author = {Veronese, M. and Zanotti-Fregonara, P. and Rizzo, G. and Bertoldo, A. and Innis, R.B. and Turkheimer, F.E.},
year = {2016},
date = {2016-07-13},
booktitle = {Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016)},
organization = {Boston (MA, USA), 13-17 July 2016 },
note = {oral},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Veronese, M; Moro, L; Rizzo, G; Expert, P; Khan, W; Bertoldo, A; F.E., Turkheimer Network analysis of brain PET data: application to cross-sectional studies Conference Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016), Boston (MA, USA), 13-17 July 2016 , 2016, (poster). BibTeX @conference{Veronese2016NRM2,
title = {Network analysis of brain PET data: application to cross-sectional studies},
author = {Veronese, M. and Moro, L. and Rizzo, G. and Expert, P and Khan, W. and Bertoldo, A. and Turkheimer F.E.},
year = {2016},
date = {2016-07-13},
booktitle = {Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016)},
address = {Boston (MA, USA), 13-17 July 2016 },
note = {poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Tonietto M., ; Rizzo, G; Veronese, M; Bertoldo, A A unified framework for the automatic blood data modelling in dynamic PET studies Conference Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016), Boston (MA, USA), 13-17 July 2016 , 2016, (poster). BibTeX @conference{Tonietto2016NRM,
title = {A unified framework for the automatic blood data modelling in dynamic PET studies},
author = {Tonietto, M., and Rizzo, G. and Veronese, M. and Bertoldo, A.},
year = {2016},
date = {2016-07-13},
booktitle = {Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016)},
address = {Boston (MA, USA), 13-17 July 2016 },
note = {poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
McGinnity, C J; Riaño Barros, D A; Rosso, L; Veronese, M; Rizzo, G; Hinz, R; Turkheimer, F E; Koepp, M J; Hammers, A Test-retest reproducibility of [11C]Ro15 4513, a PET ligand for GABAA receptors containing alpha 5 subunits Conference Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016), Boston (MA, USA), 13-17 July 2016 , 2016, (poster). BibTeX @conference{McGinnity2016NRM,
title = {Test-retest reproducibility of [11C]Ro15 4513, a PET ligand for GABAA receptors containing alpha 5 subunits},
author = {McGinnity, C.J. and Riaño, Barros, D.A. and Rosso, L. and Veronese, M. and Rizzo, G. and Hinz, R. and Turkheimer, F.E. and Koepp, M.J. and Hammers, A.},
year = {2016},
date = {2016-07-13},
booktitle = {Eleventh International Symposium on Functional Neuroreceptor Mapping of the Living Brain, (NeuroReceptor Mapping 2016)},
address = {Boston (MA, USA), 13-17 July 2016 },
note = {poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Zanotti-Fregonara, P; Veronese, M; Rizzo, G; Bertoldo, A; Innis, R B; Turkheimer, F E A new method for measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade Conference J Nucl Med Meeting Abstracts, SNMMI 2016 San Diego (CA, USA), , 2016, (in press, poster). BibTeX @conference{Zanotti2016NRM,
title = {A new method for measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade},
author = {Zanotti-Fregonara, P. and Veronese, M. and Rizzo, G. and Bertoldo, A. and Innis, R.B. and Turkheimer, F.E.},
year = {2016},
date = {2016-07-13},
booktitle = {J Nucl Med Meeting Abstracts},
address = {San Diego (CA, USA), },
organization = {SNMMI 2016},
note = {in press, poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Hellyer, P J; Barry, E; Pellizzon, A; Veronese, M; Rizzo, G; Bertoldo, A; Tonietto, M; Turkheimer, F E Exploring the relationship between structure, multi-scale functional dynamics and objective measurements of neural plasticity Conference Organization for Human Brain Mapping, (OHBM 2016), Organization for Human Brain Mapping 2016, (poster). BibTeX @conference{Hellyer2016Conf,
title = {Exploring the relationship between structure, multi-scale functional dynamics and objective measurements of neural plasticity},
author = {Hellyer, P.J. and Barry, E. and Pellizzon, A. and Veronese, M. and Rizzo, G. and Bertoldo, A. and Tonietto, M. and Turkheimer, F.E.},
year = {2016},
date = {2016-06-26},
booktitle = {Organization for Human Brain Mapping, (OHBM 2016)},
organization = {Organization for Human Brain Mapping},
note = {poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Raffeiner, B; Grisan, E; Rizzo, G; Botsios, C; Doria, A; Ometto, F; Punzi, L Presence, grade and location of power doppler predict progression of radiographic damage in TNFα blocker induced clinical remission in rheumatoid arthritis patients Conference Annals of Rheumatic Diseases, Annual meeting of European League Against Rheumatism (EULAR 2016) London, UK, 8-11 June 2016, 2016, (in press, poster). Links | BibTeX @conference{Raffeiner2016EULAR,
title = {Presence, grade and location of power doppler predict progression of radiographic damage in TNFα blocker induced clinical remission in rheumatoid arthritis patients},
author = {Raffeiner, B. and Grisan, E. and Rizzo, G. and Botsios, C. and Doria, A. and Ometto, F. and Punzi, L.},
doi = {10.1136/annrheumdis-2016-eular.3323},
year = {2016},
date = {2016-06-08},
booktitle = {Annals of Rheumatic Diseases},
address = {London, UK, 8-11 June 2016},
organization = {Annual meeting of European League Against Rheumatism (EULAR 2016)},
note = {in press, poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Selvaraj, S; Bloomfield, P; Veronese, M; Rizzo, G; Bertoldo, A; Owen, D R; Bloomfield, M; Bonoldi, I; Kalk, N; Turkheimer, F E; McGuire, P; De Paola, V; OD., Howes Elevated Translocator Protein (TSPO) in Subjects at High Risk of Psychosis and in Schizophrenia: an [11C] PBR28 PET Brain Imaging Study Conference 2016 International Society for CNS Clinical Trials and Methodology (ISCTM) 12th Annual Scientific Meeting, 2016, (poster). BibTeX @conference{Selvaraj2016,
title = {Elevated Translocator Protein (TSPO) in Subjects at High Risk of Psychosis and in Schizophrenia: an [11C] PBR28 PET Brain Imaging Study},
author = {Selvaraj,S. and Bloomfield, P. and Veronese, M. and Rizzo, G. and Bertoldo, A. and Owen, D.R. and Bloomfield, M. and Bonoldi, I. and Kalk, N. and Turkheimer, F.E. and McGuire, P. and De Paola, V. and Howes OD. },
year = {2016},
date = {2016-02-16},
booktitle = {2016 International Society for CNS Clinical Trials and Methodology (ISCTM) 12th Annual Scientific Meeting},
note = {poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
G. Tarroni S. Visentin, Cosmi Grisan E E A fully automated approach to aortic distensibility quantification from fetal ultrasound images Conference Computing in Cardiology, 42 (7411014), 2016, ISBN: 23258861. Links | BibTeX @conference{tarroni_2016_cinc,
title = {A fully automated approach to aortic distensibility quantification from fetal ultrasound images},
author = {G. Tarroni,
S. Visentin,
E. Cosmi,
E. Grisan},
doi = {10.1109/CIC.2015.7411014},
isbn = {23258861},
year = {2016},
date = {2016-02-16},
booktitle = {Computing in Cardiology},
volume = {42},
number = {7411014},
pages = {729-732},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Roberta Magliozzi; Massimiliano, Calabrese; Carolina Cruciani; Stefania Rossi; Marco Castellaro; Rachel James; Alberto Gajofatto; Maria Donata Benedetti; Chiara Romualdi; Marco Pitteri; Francesco Facchiano; Owain Howell; Salvatore Monaco; Richard Reynolds Can the degree of meningeal inflammation and cortical pathology be used to stratify early progressive MS patients? Conference ACTRIMS Forum 2016, S1 , 2016. Links | BibTeX @conference{Magliozzi2016,
title = {Can the degree of meningeal inflammation and cortical pathology be used to stratify early progressive MS patients?},
author = {Roberta, Magliozzi; Massimiliano, Calabrese; Carolina, Cruciani; Stefania, Rossi; Marco, Castellaro; Rachel, James; Alberto, Gajofatto; Maria Donata, Benedetti; Chiara, Romualdi; Marco, Pitteri; Francesco, Facchiano; Owain, Howell; Salvatore, Monaco; Richard, Reynolds},
doi = {10.1177/1352458516631279},
year = {2016},
date = {2016-02-01},
booktitle = {ACTRIMS Forum 2016},
volume = {S1},
pages = {62},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Boschetto, Davide; Gambaretto, Gloria; Grisan, Enrico Automatic Classification of Endoscopic Images for Premalignant Conditions of the Esophagus Conference SPIE Medical Imaging 2016, 2016. BibTeX @conference{spie16_boschetto_a,
title = {Automatic Classification of Endoscopic Images for Premalignant Conditions of the Esophagus},
author = { Davide Boschetto and Gloria Gambaretto and Enrico Grisan},
year = {2016},
date = {2016-01-01},
booktitle = {SPIE Medical Imaging 2016},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Boschetto, Davide; Claudio, Gianluca Di; Mirzaei, Hadis; Leong, Rupert; Grisan, Enrico Automatic Classification of Small Bowel Mucosa Alterations in Celiac Disease for Confocal Laser Endomicroscopy Conference SPIE Medical Imaging 2016, 2016. BibTeX @conference{spie16_boschetto_b,
title = {Automatic Classification of Small Bowel Mucosa Alterations in Celiac Disease for Confocal Laser Endomicroscopy},
author = { Davide Boschetto and Gianluca Di Claudio and Hadis Mirzaei and Rupert Leong and Enrico Grisan},
year = {2016},
date = {2016-01-01},
booktitle = {SPIE Medical Imaging 2016},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Boschetto, Davide; Gambaretto, Gloria; Grisan, Enrico Superpixel-based automatic segmentation of villi in confocal endomicroscopy Conference IEEE Biomedical and Health Informatics, 2016. BibTeX @conference{bhi16,
title = {Superpixel-based automatic segmentation of villi in confocal endomicroscopy},
author = {Davide Boschetto and Gloria Gambaretto and Enrico Grisan},
year = {2016},
date = {2016-01-01},
booktitle = {IEEE Biomedical and Health Informatics},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
2015
|
Selvaraj, Sudhakar; Bloomfield, Peter; Veronese, Mattia; Rizzo, Gaia; Bertoldo, Alessandra; Owen, David; Bloomfield, Michael; Bonoldi, Ilaria; Kalk, Nicola; Turkheimer, Federico; Mcguire, Philip; de Paola, Vincenzo; Howes, Oliver Imaging Translocator Protein (TSPO) in Subjects at High Risk of Psychosis and in Schizophrenia: An [11C] PBR28 Pet Brain Imaging Study Conference 40 (1), Amer Coll Neuropsychopharmacol NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2015, ISSN: 0893-133X, (54th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Hollywood, FL, DEC 06-10, 2015). BibTeX @conference{ISI:000366597700906,
title = {Imaging Translocator Protein (TSPO) in Subjects at High Risk of Psychosis and in Schizophrenia: An [11C] PBR28 Pet Brain Imaging Study},
author = { Sudhakar Selvaraj and Peter Bloomfield and Mattia Veronese and Gaia Rizzo and Alessandra Bertoldo and David Owen and Michael Bloomfield and Ilaria Bonoldi and Nicola Kalk and Federico Turkheimer and Philip Mcguire and Vincenzo de Paola and Oliver Howes},
issn = {0893-133X},
year = {2015},
date = {2015-12-01},
journal = {NEUROPSYCHOPHARMACOLOGY},
volume = {40},
number = {1},
pages = {S559-S560},
publisher = {NATURE PUBLISHING GROUP},
address = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND},
organization = {Amer Coll Neuropsychopharmacol},
note = {54th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Hollywood, FL, DEC 06-10, 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Palombit, Alessandro; Castellaro, Marco; Tonietto, Matteo; Silvestri, Erica; Calabrese, Massimiliano; Bertoldo, Alessandra Comparative Assessment of Methods for Quantitative Susceptibility Mapping on a Clinical Magnetic Resonance Data Set Conference 37th annual international conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Milan, Italy, 2015. BibTeX @conference{palombit_2015_EMBC,
title = {Comparative Assessment of Methods for Quantitative Susceptibility Mapping on a Clinical Magnetic Resonance Data Set},
author = {Palombit,Alessandro and Castellaro,Marco and Tonietto,Matteo and Silvestri,Erica and Calabrese,Massimiliano and Bertoldo,Alessandra
},
year = {2015},
date = {2015-07-01},
booktitle = {37th annual international conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Milan, Italy},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Sabrina, Brigadoi; Simone, Cutini; Federica, Meconi; Marco, Castellaro; Paola, Sessa; Mattia, Marangon; Alessandra, Bertoldo; D., Miotto; Roberto, Dell'Acqua The neural substrate of lateralized visual short-term memory representations Conference 21st annual meeting of Organization For Human Brain Mapping – OHBM 2015, 2015. BibTeX @conference{Brigadoi2015,
title = {The neural substrate of lateralized visual short-term memory representations},
author = {Brigadoi Sabrina and Cutini Simone and Meconi Federica and Castellaro Marco and Sessa Paola and Marangon Mattia and Bertoldo Alessandra and Miotto D. and Dell'Acqua Roberto},
year = {2015},
date = {2015-06-01},
booktitle = {21st annual meeting of Organization For Human Brain Mapping – OHBM 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rossignoli, P; Tiso, N; Santagiustina, M; Autizi, E; Grisan, E; Palmieri, L Polarization sensitive optical coherence tomography for zebrafish imaging Conference IET Conference Publications
, 2015 (CP667), Institution of Engineering and Technology, 2015. Links | BibTeX @conference{rossignoli15,
title = {Polarization sensitive optical coherence tomography for zebrafish imaging},
author = {P. Rossignoli and N. Tiso and M. Santagiustina and E. Autizi and E. Grisan and L. Palmieri},
doi = {10.1049/cp.2015.0176},
year = {2015},
date = {2015-05-06},
booktitle = {IET Conference Publications
},
volume = {2015},
number = {CP667},
publisher = {Institution of Engineering and Technology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Grisan, Enrico; Cantisani, Giorgia; Tarroni, Giacomo; Rossi, Michele A Supervised Learning Approach for the Robust Detection of Heart Beat in Plethysmographic Data Conference Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology, 2015, (37th Annual International Conference of the IEEE Engineering in Medicine and Biology). BibTeX @conference{Grisan2015,
title = {A Supervised Learning Approach for the Robust Detection of Heart Beat in Plethysmographic Data},
author = { Enrico Grisan and Giorgia Cantisani and Giacomo Tarroni and Michele Rossi},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
journal = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
pages = {-},
note = {37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Francescon, Roberto; Hooshmand, Mohsen; Gadaleta, Matteo; Grisan, Enrico; Rossi, Michele Toward Lightweight Biometric Signal Processing for Wearable Devices Conference Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology, 2015, (37th Annual International Conference of the IEEE Engineering in Medicine and Biology). BibTeX @conference{Francescon2015,
title = {Toward Lightweight Biometric Signal Processing for Wearable Devices},
author = { Roberto Francescon and Mohsen Hooshmand and Matteo Gadaleta and Enrico Grisan and Michele Rossi},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
journal = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
pages = {-},
note = {37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Cerrolaza, Juan J; Grisan, Enrico; Safdar, Nabile; Myers, Emmarie; Jago, James; Peters, Craig A; Linguraru, Marius George Quantification of Kidneys from 3D Ultrasound in Pediatric Hydronephrosis Conference Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology, 2015, (37th Annual International Conference of the IEEE Engineering in Medicine and Biology). BibTeX @conference{Cerrolaza2015,
title = {Quantification of Kidneys from 3D Ultrasound in Pediatric Hydronephrosis},
author = { J. Juan Cerrolaza and Enrico Grisan and Nabile Safdar and Emmarie Myers and James Jago and Craig A. Peters and Marius George Linguraru},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
journal = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
pages = {-},
note = {37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Tarroni, Giacomo; Visentin, Silvia; Cosmi, Erich; Grisan, Enrico Fully-Automated Identification and Segmentation of Aortic Lumen from Fetal Ultrasound Images Conference Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology, 2015, (37th Annual International Conference of the IEEE Engineering in Medicine and Biology). BibTeX @conference{Tarroni2015c,
title = {Fully-Automated Identification and Segmentation of Aortic Lumen from Fetal Ultrasound Images},
author = { Giacomo Tarroni and Silvia Visentin and Erich Cosmi and Enrico Grisan},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
journal = {Proceedings - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
pages = {-},
note = {37th Annual International Conference of the IEEE Engineering in Medicine and Biology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Tonietto, Matteo; Mazzonetto, Ilaria; Monaco, Salvatore; Calabrese, Massimiliano; Castellaro, Marco; Bertoldo, Alessandra Effective and functional connectivity in the motor cortex are sensitive to disability in MS Conference 21st annual meeting of Organization For Human Brain Mapping – OHBM 2015, 2015. BibTeX @conference{Tonietto2015ab,
title = {Effective and functional connectivity in the motor cortex are sensitive to disability in MS},
author = { Matteo Tonietto and Ilaria Mazzonetto and Salvatore Monaco and Massimiliano Calabrese and Marco Castellaro and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {21st annual meeting of Organization For Human Brain Mapping – OHBM 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Tonietto, Matteo; Rizzo, Gaia; Veronese, Mattia; Bertoldo, Alessandra Modelling arterial input functions in Positron Emission Tomography dynamic studies Conference 37th annual international conference of the IEEE Engineering in Medicine and Biology Society – EMBC 2015, 2015, ISBN: 978-1-4244-9271-8. Links | BibTeX @conference{Tonietto2015bb,
title = {Modelling arterial input functions in Positron Emission Tomography dynamic studies},
author = { Matteo Tonietto and Gaia Rizzo and Mattia Veronese and Alessandra Bertoldo},
url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7318839},
doi = {10.1109/EMBC.2015.7318839},
isbn = {978-1-4244-9271-8},
year = {2015},
date = {2015-01-01},
booktitle = {37th annual international conference of the IEEE Engineering in Medicine and Biology Society – EMBC 2015},
pages = {2247-2250},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Tonietto, Matteo; Calabrese, Massimiliano; Silvestri, Erica; Morra, Aldo; Castellaro, Marco; Monaco, Salvatore; Bertoldo, Alessandra Use of cortical thickness to detect localized damage in the somatomotor cortex in MS: relation with clinical disability. Conference 31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS 2015, 2015. BibTeX @conference{Tonietto2015c,
title = {Use of cortical thickness to detect localized damage in the somatomotor cortex in MS: relation with clinical disability.},
author = { Matteo Tonietto and Massimiliano Calabrese and Erica Silvestri and Aldo Morra and Marco Castellaro and Salvatore Monaco and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rizzo, Gaia; Veronese, Mattia; Zanotti-Fregonara, Paolo; Turkheimer, Federico E; Bertoldo, Alessandra Spectral-based quantification of [11C]PBR28 brain PET data Conference Hot Topic in Molecular Imaging – TOPIM 2015, 2015. BibTeX @conference{Rizzo2015a,
title = {Spectral-based quantification of [11C]PBR28 brain PET data},
author = { Gaia Rizzo and Mattia Veronese and Paolo Zanotti-Fregonara and Federico E. Turkheimer and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Hot Topic in Molecular Imaging – TOPIM 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Veronese, Mattia; Rizzo, Gaia; Zanotti-Fregonara, Paolo; Turkheimer, Federico E; Bertoldo, Alessandra Voxel-wise quantification of [11C]BBR28 brain data accounting for endothelial TSPO binding Conference Hot Topic in Molecular Imaging – TOPIM 2015, 2015. BibTeX @conference{Veronese2015a,
title = {Voxel-wise quantification of [11C]BBR28 brain data accounting for endothelial TSPO binding},
author = { Mattia Veronese and Gaia Rizzo and Paolo Zanotti-Fregonara and Federico E. Turkheimer and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Hot Topic in Molecular Imaging – TOPIM 2015},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Selvaraj, S; Bloomfield, P; Veronese, M; Rizzo, G; Bertoldo, A; Owen, D R; Bloomfield, M; Bonoldi, I; Kalk, N; Federico, T; McGuire, P; Paola, De V; Howes, O Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An 11C PBR28 PET Brain Imaging Study Conference Biological Psychiatry, 77 (9), 2015, ISSN: 0006-3223. Links | BibTeX @conference{Selvaraj2015,
title = {Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An 11C PBR28 PET Brain Imaging Study},
author = { S. Selvaraj and P. Bloomfield and M. Veronese and G. Rizzo and A. Bertoldo and D. R. Owen and M. Bloomfield and I. Bonoldi and N. Kalk and T. Federico and P. McGuire and V. De Paola and O. Howes},
url = {<Go to ISI>://WOS:000352207501104},
issn = {0006-3223},
year = {2015},
date = {2015-01-01},
booktitle = {Biological Psychiatry},
journal = {Biological Psychiatry},
volume = {77},
number = {9},
pages = {1},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Castellaro, Marco; Palombit, Alessandro; Silvestri, Erica; Tonietto, Matteo; Gajofatto, Alberto; Montemezzi, Stefania; Magliozzi, Roberta; Howell, O W; Reynolds, Richard; Monaco, Salvatore; Bertoldo, Alessandra; Calabrese, Massimiliano Heterogeneity of susceptibility mapping of cortical lesions in MS Conference 31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain, 2015. BibTeX @conference{Castellaro2015_SWI,
title = {Heterogeneity of susceptibility mapping of cortical lesions in MS},
author = { Marco Castellaro and Alessandro Palombit and Erica Silvestri and Matteo Tonietto and Alberto Gajofatto and Stefania Montemezzi and Roberta Magliozzi and O.W. Howell and Richard Reynolds and Salvatore Monaco and Alessandra Bertoldo and Massimiliano Calabrese},
year = {2015},
date = {2015-01-01},
booktitle = {31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Veronese, Mattia; Rizzo, Gaia; Expert, Paul; Bertoldo, Alessandra; Turkheimer, Federico E Multimodal Environment for Neuroimaging and Genomic Analysis: MENGA Conference 2015 International Conference on Brain & Health Informatics - BIH'15, 2015. BibTeX @conference{Veronese2015b,
title = {Multimodal Environment for Neuroimaging and Genomic Analysis: MENGA},
author = { Mattia Veronese and Gaia Rizzo and Paul Expert and Alessandra Bertoldo and Federico E. Turkheimer},
year = {2015},
date = {2015-01-01},
booktitle = {2015 International Conference on Brain & Health Informatics - BIH'15},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Castellaro, Marco; Bertoldo, Alessandra; Morra, Aldo; Monaco, Salvatore; Calabrese, Massimiliano; Doyle, Orla Prediction of conversion to secondary progression phase in multiple sclerosis Conference 31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain, 2015. BibTeX @conference{Castellaro2015_ML,
title = {Prediction of conversion to secondary progression phase in multiple sclerosis},
author = { Marco Castellaro and Alessandra Bertoldo and Aldo Morra and Salvatore Monaco and Massimiliano Calabrese and Orla Doyle},
year = {2015},
date = {2015-01-01},
booktitle = {31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rizzo, Gaia; Veronese, Mattia; Expert, Paul; Turkheimer, Federico E; Bertoldo, Alessandra MENGA: a comprehensive tool for the integration of brain imaging modalities and Allen brain genomic atlas Conference Molecular Imaging and Biology, 2015, (in press). BibTeX @conference{Rizzo2015b,
title = {MENGA: a comprehensive tool for the integration of brain imaging modalities and Allen brain genomic atlas},
author = { Gaia Rizzo and Mattia Veronese and Paul Expert and Federico E. Turkheimer and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Molecular Imaging and Biology},
journal = {Molecular Imaging and Biology},
note = {in press},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Calabrese, Massimiliano; Castellaro, Marco; Luca, Alberto De; Pizzini, F B; Magliozzi, R; Zimatore, S; Ricciardi, G K; Montemezzi, Stefania; Benedetti, M D; Pitteri, Marco; Farina, Gabriele; Bertoldo, Alessandra; Gajofatto, Alberto; Reynolds, Richard; Howell, O; Manganotti, Paolo; Monaco, Salvatore Temporal lobe damage is linked to epilepsy in multiple sclerosis patients Conference 31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain, 2015. BibTeX @conference{Calabrese2015_temporal_lobe,
title = {Temporal lobe damage is linked to epilepsy in multiple sclerosis patients},
author = { Massimiliano Calabrese and Marco Castellaro and Alberto De Luca and F.B. Pizzini and R. Magliozzi and S. Zimatore and G.K. Ricciardi and Stefania Montemezzi and M.D. Benedetti and Marco Pitteri and Gabriele Farina and Alessandra Bertoldo and Alberto Gajofatto and Richard Reynolds and O. Howell and Paolo Manganotti and Salvatore Monaco},
year = {2015},
date = {2015-01-01},
booktitle = {31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Rizzo, Gaia; Tonietto, Matteo; Zanoni, Simone; Chappell, Michael A; Castellaro, Marco; Bertoldo, Alessandra Use of a Variational Bayesian inference approach for the quantification of brain PET data at the voxel level Conference Molecular Imaging and Biology, 2015, (in press). BibTeX @conference{Rizzo2015cb,
title = {Use of a Variational Bayesian inference approach for the quantification of brain PET data at the voxel level},
author = { Gaia Rizzo and Matteo Tonietto and Simone Zanoni and Michael A. Chappell and Marco Castellaro and Alessandra Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Molecular Imaging and Biology},
journal = {Molecular Imaging and Biology},
note = {in press},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Magliozzi, Roberta; Facchiano, F; Rossi, S; Castellaro, Marco; Gajofatto, Alberto; Howell, O; Benedetti, M D; Monaco, Salvatore; Reynolds, Richard; Calabrese, Massimiliano Predicting the disease progression: a combined CSF and MRI longitudinal study on grey matter damage in multiple sclerosis Conference MS Frontiers 2015, Annual Meeting of the UK MS Society, London, 2015. Links | BibTeX @conference{Magliozzi2015_MS_Frontiers,
title = {Predicting the disease progression: a combined CSF and MRI longitudinal study on grey matter damage in multiple sclerosis},
author = { Roberta Magliozzi and F. Facchiano and S. Rossi and Marco Castellaro and Alberto Gajofatto and O. Howell and M.D. Benedetti and Salvatore Monaco and Richard Reynolds and Massimiliano Calabrese},
url = {http://www.mssociety.org.uk/sites/default/files/MS%20Frontiers%20Handbook%202015.pdf pages63},
year = {2015},
date = {2015-01-01},
booktitle = {MS Frontiers 2015, Annual Meeting of the UK MS Society, London},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Luca, Alberto De; Castellaro, Marco; Montemezzi, Stefania; Calabrese, Massimiliano; Bertoldo, Alessandro Tissue separation of multi-shell DW-MRI with a physiologically constrained multi compartment model and spherical deconvolution Conference Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, 2015. BibTeX @conference{Deluca2015_ISMRM_DWI,
title = {Tissue separation of multi-shell DW-MRI with a physiologically constrained multi compartment model and spherical deconvolution},
author = { Alberto De Luca and Marco Castellaro and Stefania Montemezzi and Massimiliano Calabrese and Alessandro Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Castellaro, Marco; Bertoldo, Alessandra; Peruzzo, Denis; Arrigoni, Filippo; Osch, Matthias Van Improving Look & Locker readout for pCASL using a variable Flip Angle sweep Conference Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, 2015. BibTeX @conference{Castellaro2015_ISMRM_vFA,
title = {Improving Look & Locker readout for pCASL using a variable Flip Angle sweep},
author = { Marco Castellaro and Alessandra Bertoldo and Denis Peruzzo and Filippo Arrigoni and Matthias Van Osch},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Luca, Alberto De; Peruzzo, Denis; Triulzi, Fabio; Arrigoni, Filippo; Bertoldo, Alessandro An automatic classificator based on local fractal features for the identification of cortical malformations Conference Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, 2015. BibTeX @conference{Deluca2015_ISMRM_frattali,
title = {An automatic classificator based on local fractal features for the identification of cortical malformations},
author = { Alberto De Luca and Denis Peruzzo and Fabio Triulzi and Filippo Arrigoni and Alessandro Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Luca, Alberto De; Castellaro, Marco; Montemezzi, Stefania; Calabrese, Massimiliano; Bertoldo, Alessandro Hippocampi and epilepsy in MS patients: a diffusion weighted imaging study with NODDI Conference Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, 2015. BibTeX @conference{Deluca2015_ISMRM_MS_Hyppo,
title = {Hippocampi and epilepsy in MS patients: a diffusion weighted imaging study with NODDI},
author = { Alberto De Luca and Marco Castellaro and Stefania Montemezzi and Massimiliano Calabrese and Alessandro Bertoldo},
year = {2015},
date = {2015-01-01},
booktitle = {Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Canada},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Magliozzi, Roberta; Facchiano, F; Rossi, S; Castellaro, Marco; Gajofatto, Alberto; Montemezzi, Stefania; Pizzini, F B; Bertoldo, Alessandra; Pitteri, M; Benedetti, M D; Howell, O; Monaco, Salvatore; Reynolds, Richard; Calabrese, Massimiliano Combined CSF and MRI longitudinal study of grey matter damage in multiple sclerosis may allow prediction and monitoring of disease progression Conference 31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain, 2015. BibTeX @conference{Magliozzi2015_MS_ECTRIMS,
title = {Combined CSF and MRI longitudinal study of grey matter damage in multiple sclerosis may allow prediction and monitoring of disease progression},
author = { Roberta Magliozzi and F. Facchiano and S. Rossi and Marco Castellaro and Alberto Gajofatto and Stefania Montemezzi and F.B. Pizzini and Alessandra Bertoldo and M. Pitteri and M.D. Benedetti and O. Howell and Salvatore Monaco and Richard Reynolds and Massimiliano Calabrese},
year = {2015},
date = {2015-01-01},
booktitle = {31st congress of the European committee for treatment and research in Multiple Sclerosis – ECTRIMS, Barcellona, Spain},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
Boschetto, Davide; Mirzaei, Hadis; Leong, Rupert; Grisan, Enrico Detection and Density Estimation of Goblet Cells in Confocal Endoscopy for the Evaluation of Celiac Disease Conference 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2015. BibTeX @conference{embc15_mucine,
title = {Detection and Density Estimation of Goblet Cells in Confocal Endoscopy for the Evaluation of Celiac Disease},
author = { Davide Boschetto and Hadis Mirzaei and Rupert Leong and Enrico Grisan},
year = {2015},
date = {2015-01-01},
booktitle = {2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
publisher = {Engineering in Medicine and Biology Society (EMBC)},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
|
