The manual analysis of the karyogram is a complex and time-consuming operation, as it requires meticulous attention to details and well-trained personnel. Routine Q-Band laboratory images show chromosomes, which are randomly rotated, blurred or corrupted by overlapping and by dye stains.
The work is aimed at the development and realization of algorithms for the segmentation, disentangling and subsequent classification of chromosomes from Q-band prometaphase images, and finally classify each segmented chromosome into one of the 22 chromosomes class or sexual chromosome (X or Y)
Confocal laser endomicroscopy (CLE) is a new technology for the observation of cellular morphology during ongoing endoscopy (in-vivo virtual histology). The evaluation of the cellular architecture characteristics and of the functional and morphological alterations of the oesphageal, gastric and intestinal mucosa may reduce the need of multiple biopsies to establish the presence of metaplastic changes, celiac disease, irritable bowels syndrome.
We aim at developing an automatic system for the diagnosis of the different pathologies and for the extraction of the quantitative biomarkers from confocal images.
White light/NBI endoscopy
Optical biopsy techniques such as white light endoscopic examinations and narrow band imaging are powerful tools for real time detection of suspicious areas and for guiding biopsies. However, the low accuracy and the low inter-observer agreement limit the exploitation of the full potential of endoscopic analysis.
Our aim is to develop computer-aided tools for the detection of metaplastic and neoplastic tissues from white light and NBI images.